Prokaryotic Transcriptomics: a New View on Regulation, Physiology and Pathogenicity

Overview

Journal Nat Rev Genet

Specialty Genetics

Date 2009 Nov 26

PMID 19935729

Citations 188

Authors

Rotem Sorek

Pascale Cossart

Affiliations

Soon will be listed here.

Abstract

Transcriptome-wide studies in eukaryotes have been instrumental in the characterization of fundamental regulatory mechanisms for more than a decade. By contrast, in prokaryotes (bacteria and archaea) whole-transcriptome studies have not been performed until recently owing to the general view that microbial gene structures are simple, as well as technical difficulties in enriching for mRNAs that lack poly(A) tails. Deep RNA sequencing and tiling array studies are now revolutionizing our understanding of the complexity, plasticity and regulation of microbial transcriptomes.

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