Innate Immunity

Overview

Journal J Allergy Clin Immunol

Specialty Allergy & Immunology

Date 2009 Nov 26

PMID 19932920

Citations 162

Authors

Stuart E Turvey

David H Broide

Affiliations

Soon will be listed here.

Abstract

Recent years have witnessed an explosion of interest in the innate immune system. Questions about how the innate immune system senses infection and empowers a protective immune response are being answered at the molecular level. These basic science discoveries are being translated into a more complete understanding of the central role innate immunity plays in the pathogenesis of many human infectious and inflammatory diseases. It is particularly exciting that we are already seeing a return on these scientific investments with the emergence of novel therapies to harness the power of the innate immune system. In this review we explore the defining characteristics of the innate immune system, and through more detailed examples, we highlight recent breakthroughs that have advanced our understanding of the role of innate immunity in human health and disease.

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