Attenuation by Dextromethorphan on the Higher Liability to Morphine-induced Reward, Caused by Prenatal Exposure of Morphine in Rat Offspring

Overview

Journal J Biomed Sci

Publisher Biomed Central

Specialty Biology

Date 2009 Nov 26

PMID 19930722

Citations 18

Authors

Ling-Yi Wu

Jain-Fang Chen

Pao-Luh Tao

Eagle Yi-Kung Huang

Affiliations

Soon will be listed here.

Abstract

Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring. No evidence was presented, however, for the effect of DM co-administered with morphine during pregnancy on morphine-induced reward and behavioral sensitization (possibly related to the potential to induce morphine addiction) in morphine-exposed offspring. Conditioned place preference and locomotor activity tests revealed that the p60 male offspring of chronic morphine-treated female rats were more vulnerable to morphine-induced reward and behavioral sensitization. The administration of a low dose of morphine (1 mg/kg, i.p.) in these male offspring also increased the dopamine and serotonin turnover rates in the nucleus accumbens, which implied that they were more sensitive to morphine. Co-administration of DM with morphine in the dams prevented this adverse effect of morphine in the offspring rats. Thus, DM may possibly have a great potential in the prevention of higher vulnerability to psychological dependence of morphine in the offspring of morphine-addicted mothers.

Citing Articles

Serotonergic Regulation of Synaptic Dopamine Levels Mitigates L-DOPA-Induced Dyskinesia in a Mouse Model of Parkinson's Disease.

Chen Y, Kuo T, Wang V, Cheng P, Yi-Kung Huang E, Ma K J Parkinsons Dis. 2024; 14(5):941-964.

PMID: 38905058 PMC: 11307072. DOI: 10.3233/JPD-240080.

Perigestational Opioid Exposure Alters Alcohol-Driven Reward Behaviors in Adolescent Rats.

Searles C, Harder H, Vogt M, Murphy A bioRxiv. 2023; .

PMID: 38014019 PMC: 10680700. DOI: 10.1101/2023.11.14.567041.

Molecular and long-term behavioral consequences of neonatal opioid exposure and withdrawal in mice.

Dunn A, Robinson S, Nwokafor C, Estill M, Ferrante J, Shen L Front Behav Neurosci. 2023; 17:1202099.

PMID: 37424750 PMC: 10324024. DOI: 10.3389/fnbeh.2023.1202099.

Perinatal opioid exposure leads to decreased social play in adolescent male and female rats: Potential role of oxytocin signaling in brain regions associated with social reward.

Harder H, Searles C, Vogt M, Murphy A Horm Behav. 2023; 153:105384.

PMID: 37295323 PMC: 10330883. DOI: 10.1016/j.yhbeh.2023.105384.

Perinatal Opioid Exposure Leads to Decreased Social Play in Adolescent Male and Female Rats: Potential Role of Oxytocin Signaling in Brain Regions Associated with Social Reward.

Harder H, Searles C, Vogt M, Murphy A bioRxiv. 2023; .

PMID: 36945450 PMC: 10028981. DOI: 10.1101/2023.03.10.532122.

References

Klein M, Musacchio J . High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents. J Pharmacol Exp Ther. 1989; 251(1):207-15. View

Trujillo K, Akil H . Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science. 1991; 251(4989):85-7. DOI: 10.1126/science.1824728. View

Vezina P, Stewart J . Conditioning and place-specific sensitization of increases in activity induced by morphine in the VTA. Pharmacol Biochem Behav. 1984; 20(6):925-34. DOI: 10.1016/0091-3057(84)90018-2. View

Gagin R, KOOK N, Cohen E, Shavit Y . Prenatal morphine enhances morphine-conditioned place preference in adult rats. Pharmacol Biochem Behav. 1997; 58(2):525-8. DOI: 10.1016/s0091-3057(97)00281-5. View

Wroblewski J, Danysz W . Modulation of glutamate receptors: molecular mechanisms and functional implications. Annu Rev Pharmacol Toxicol. 1989; 29:441-74. DOI: 10.1146/annurev.pa.29.040189.002301. View

Vargas G, Pildes R, Vidyasagar D, Keith L . Effect of maternal heroin addiction on 67 liveborn neonates. Withdrawal symptoms, small body size, and small head circumference were frequent findings. Clin Pediatr (Phila). 1975; 14(8):751-3 passim. DOI: 10.1177/000992287501400811. View

Suzuki T, Kato H, Aoki T, Tsuda M, Narita M, Misawa M . Effects of the non-competitive NMDA receptor antagonist ketamine on morphine-induced place preference in mice. Life Sci. 2000; 67(4):383-9. DOI: 10.1016/s0024-3205(00)00639-1. View

Brady L, Holtzman S . Locomotor activity in morphine-dependent and post-dependent rats. Pharmacol Biochem Behav. 1981; 14(3):361-70. DOI: 10.1016/0091-3057(81)90403-2. View

Robinson T, Berridge K . The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev. 1993; 18(3):247-91. DOI: 10.1016/0165-0173(93)90013-p. View

10.

COBRINIK R, HOOD Jr R, CHUSID E . The effect of maternal narcotic addiction on the newborn infant; review of literature and report of 22 cases. Pediatrics. 1959; 24(2):288-304. View

11.

Tzschentke T . Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues. Prog Neurobiol. 1999; 56(6):613-72. DOI: 10.1016/s0301-0082(98)00060-4. View

12.

Church J, Sawyer D, McLarnon J . Interactions of dextromethorphan with the N-methyl-D-aspartate receptor-channel complex: single channel recordings. Brain Res. 1994; 666(2):189-94. DOI: 10.1016/0006-8993(94)90771-4. View

13.

Wu L, Yi-Kung Huang E, Tao P . Coadministration of dextromethorphan during pregnancy and throughout lactation prevents morphine-induced hyperprolactinemia in female rats. Fertil Steril. 2009; 93(5):1686-94. DOI: 10.1016/j.fertnstert.2009.01.143. View

14.

Riley M, Vathy I . Mid- to late gestational morphine exposure does not alter the rewarding properties of morphine in adult male rats. Neuropharmacology. 2006; 51(2):295-304. DOI: 10.1016/j.neuropharm.2006.03.022. View

15.

Johnson J, LEFF M . Children of substance abusers: overview of research findings. Pediatrics. 1999; 103(5 Pt 2):1085-99. View

16.

Hernandez S, Bertolino M, Xiao Y, PRINGLE K, CARUSO F, Kellar K . Dextromethorphan and its metabolite dextrorphan block alpha3beta4 neuronal nicotinic receptors. J Pharmacol Exp Ther. 2000; 293(3):962-7. View

17.

Weitemier A, Murphy N . Accumbal dopamine and serotonin activity throughout acquisition and expression of place conditioning: correlative relationships with preference and aversion. Eur J Neurosci. 2009; 29(5):1015-26. DOI: 10.1111/j.1460-9568.2009.06652.x. View

18.

Doberczak T, Kandall S, Wilets I . Neonatal opiate abstinence syndrome in term and preterm infants. J Pediatr. 1991; 118(6):933-7. DOI: 10.1016/s0022-3476(05)82214-0. View

19.

Tao P, Yeh G, Su C, Wu Y . Co-administration of dextromethorphan during pregnancy and throughout lactation significantly decreases the adverse effects associated with chronic morphine administration in rat offspring. Life Sci. 2001; 69(20):2439-50. DOI: 10.1016/s0024-3205(01)01316-9. View

20.

Del Pozo E, Barrios M, Baeyens J . The NMDA receptor antagonist dizocilpine (MK-801) stereoselectively inhibits morphine-induced place preference conditioning in mice. Psychopharmacology (Berl). 1996; 125(3):209-13. DOI: 10.1007/BF02247330. View