Characteristics of Eight X-STR Loci for Forensic Purposes in the Chinese Population

Overview

Journal Int J Legal Med

Specialty Forensic Sciences

Date 2009 Nov 20

PMID 19924429

Citations 16

Authors

Hai-Bo Luo

Yi Ye

Yan-Yun Wang

Wei-Bo Liang

Li-Bing Yun

Miao Liao

Jing Yan

Jin Wu

Ying-Bi Li

Yi-Ping Hou

Affiliations

Soon will be listed here.

Abstract

X-chromosomal short tandem repeats (ChrX STRs) loci are used for forensic practice in recent years. Considering the unique heredity characteristics of ChrX, recombination and linkage disequilibrium (LD) among ChrX STR loci vary between male and female and different populations as well. However, there is a lack of data for analysis of recombination and linkage disequilibrium on ChrX STR loci in the Chinese population. In this work, a total of 303 unrelated individuals (203 males and 100 females) in the Chinese Han population were analyzed with Mentype Argus X-8 PCR amplification kit (DXS10135-DXS8378, DXS7132-DXS10074, HPRTB-DXS10101, and DXS10134-DXS7423). The recombination and linkage disequilibrium of the eight ChrX STR loci were investigated with HapMap LD plots and software ARLEQUIN 3.1. Allele frequencies of the eight loci and further population forensic genetic parameters were obtained. Our results revealed hotspots for recombination, and there was no obvious evidence for LD among the eight loci in the Chinese population. Our work implied that single locus frequencies rather than haplotype frequencies should be applied for forensic practice in the Chinese population.

Citing Articles

Genetic Diversity and Forensic Utility of X-STR Loci in Punjabi and Kashmiri Populations: Insights into Population Structure and Ancestry.

Khan M, Rakha A, Munawar A, Nazir S, Khan A, Khan M Genes (Basel). 2024; 15(11).

PMID: 39596584 PMC: 11593897. DOI: 10.3390/genes15111384.

Genetic characterization of the highlander Tibetan population from Qinghai-Tibet Plateau revealed by X chromosomal STRs.

Li X, Adnan A, Hadi S, Al-Qahtani W, Alwaili M, Alshaya D PLoS One. 2022; 17(8):e0271769.

PMID: 35926061 PMC: 9352086. DOI: 10.1371/journal.pone.0271769.

Genetic polymorphisms of 16 X-STR loci in the Hani population from Southwest China.

Liu L, Yao J, Huang Y, Gao L, Dai J, Yuan X Forensic Sci Res. 2022; 7(2):196-201.

PMID: 35784423 PMC: 9246014. DOI: 10.1080/20961790.2021.1877389.

Establishment of 11 linked X-STR loci within 1.1 Mb to assist with kinship testing.

Lee J, Lin C, Tsai L, Yu Y, Liao K, Linacre A Int J Legal Med. 2017; 132(4):967-973.

PMID: 28730502 DOI: 10.1007/s00414-017-1637-z.

Genetic analysis of 19 X chromosome STR loci for forensic purposes in four Chinese ethnic groups.

Yang X, Zhang X, Zhu J, Chen L, Liu C, Feng X Sci Rep. 2017; 7:42782.

PMID: 28211539 PMC: 5314363. DOI: 10.1038/srep42782.

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