Repetitive Conservative Surgery for Recurrence of Endometriosis
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We evaluated the recovery of fertility and the relief of pain symptoms in a long-term follow-up of 42 women undergoing repetitive conservative surgery for recurrent endometriosis. The mean age of the patients was 31.1 +/- 4.3 years. At the time of their second operation the disease was stage IV in 14 women, stage III in 25, and stage I in three. After reoperation, the patients were followed for a mean period of 41.8 +/- 30.3 months. Pain symptoms returned in eight women, dysmenorrhea and deep dyspareunia in eight, and pelvic pain in seven. Eight of the 28 women (28.6%) who attempted to conceive achieved a total of 13 pregnancies. The corrected pregnancy rate was 35%, and the cumulative rate at 27 months was 30.7%. A third operation was necessary in six women after a mean period of 35 months. Conservative surgery is an effective therapeutic option for infertile patients with recurrent endometriosis.
Lipophilic statins inhibit growth and reduce invasiveness of human endometrial stromal cells.
Sokalska A, Hawkins A, Yamaguchi T, Duleba A J Assist Reprod Genet. 2018; 36(3):535-541.
PMID: 30554393 PMC: 6439085. DOI: 10.1007/s10815-018-1352-9.
Cathepsin Protease Inhibition Reduces Endometriosis Lesion Establishment.
Porter K, Wieser F, Wilder C, Sidell N, Platt M Reprod Sci. 2015; 23(5):623-9.
PMID: 26482207 PMC: 5933157. DOI: 10.1177/1933719115611752.
Kereszturi A, Kozinszky Z, Daru J, Pasztor N, Sikovanyecz J, Zadori J Biomed Res Int. 2015; 2015:282301.
PMID: 26247014 PMC: 4515270. DOI: 10.1155/2015/282301.
The peritoneum is both a source and target of TGF-β in women with endometriosis.
Young V, Brown J, Saunders P, Duncan W, Horne A PLoS One. 2014; 9(9):e106773.
PMID: 25207642 PMC: 4160207. DOI: 10.1371/journal.pone.0106773.
Lesion kinetics in a non-human primate model of endometriosis.
Harirchian P, Gashaw I, Lipskind S, Braundmeier A, Hastings J, Olson M Hum Reprod. 2012; 27(8):2341-51.
PMID: 22674203 PMC: 3398680. DOI: 10.1093/humrep/des196.