Calcium-independent Phosphodiesterase Inhibitors As Putative Antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl]-2-imidazolidinones

Overview

Journal J Med Chem

Publisher American Chemical Society

Specialty Chemistry

Date 1991 Jan 1

PMID 1992129

Citations 8

Authors

N A Saccomano

F J Vinick

B K KOE

J A Nielsen

W M WHALEN

M Meltz

D Phillips

P F Thadieo

S Jung

D S Chapin

Affiliations

Soon will be listed here.

Abstract

The synthesis and biological properties of a novel series of selective calcium-independent phosphodiesterase inhibitors are described. These compounds also inhibit the specific binding of [3H]rolipram to rat brain membranes and exhibit efficacy in preclinical models of antidepressant activity in mice, such as reducing immobility in the forced-swim test and reversing reserpine-induced hypothermia. Imidazolidinones 4 and 16 were found to be the most potent compounds studied.

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