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» Articles » PMID: 19918379

Acute Limb Ischemia in a Patient with Cardiac Amyloidosis: a Case Report

Overview
Journal Cases J
Specialty General Medicine
Date 2009 Nov 18
PMID 19918379
Authors
Christos Verikokos
Marika Moschou
Evridiki Karanikola
Stephanie Vgenopoulou
John Bellos
Panagiotis Roukanas
Efthimios Avgerinos
Affiliations
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Abstract

Introduction: Cardiac amyloidosis is a manifestation of several systemic diseases known as amyloidoses. Arterial thromboembolic complications have not been reported to occur frequently, although the pathophysiology of cardiovascular amyloidosis would theoretically predispose to such manifestations.

Case Presentation: We present the case of a 52-year-old woman, who suffered from cardiac amyloidosis and was admitted to our hospital for left acute limb ischemia. An urgent embolectomy was performed, improving her clinical condition and the pathologoanatomic examination of the embolus revealed deposition of amyloid.

Conclusion: Peripheral arterial thromboembolic events in patients with amyloidosis are rare. An antiplatelet treatment is recommended in such patients with cardiac amyloidosis for the prevention of embolism.

References
1.
Halligan C, Lacy M, Rajkumar S, Dispenzieri A, Witzig T, Lust J . Natural history of thromboembolism in AL amyloidosis. Amyloid. 2006; 13(1):31-6. DOI: 10.1080/13506120500537285. View
2.
Gertz M, Lacy M, Dispenzieri A, Hayman S . Amyloidosis. Best Pract Res Clin Haematol. 2005; 18(4):709-27. DOI: 10.1016/j.beha.2005.01.030. View
3.
Hausfater P, Costedoat-Chalumeau N, Amoura Z, Cacoub P, Papo T, Grateau G . AL cardiac amyloidosis and arterial thromboembolic events. Scand J Rheumatol. 2005; 34(4):315-9. DOI: 10.1080/03009740510015203. View
4.
Feng D, Edwards W, Oh J, Chandrasekaran K, Grogan M, Martinez M . Intracardiac thrombosis and embolism in patients with cardiac amyloidosis. Circulation. 2007; 116(21):2420-6. DOI: 10.1161/CIRCULATIONAHA.107.697763. View
5.
Falk R, Comenzo R, Skinner M . The systemic amyloidoses. N Engl J Med. 1997; 337(13):898-909. DOI: 10.1056/NEJM199709253371306. View