Beyond Ribosome Rescue: TmRNA and Co-translational Processes

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 2009 Nov 17

PMID 19914241

Citations 35

Authors

Christopher S Hayes

Kenneth C Keiler

Affiliations

Soon will be listed here.

Abstract

tmRNA is a unique bi-functional RNA that acts as both a tRNA and an mRNA to enter stalled ribosomes and direct the addition of a peptide tag to the C terminus of nascent polypeptides. Despite a reasonably clear understanding of tmRNA activity, the reason for its absolute conservation throughout the eubacteria is unknown. Although tmRNA plays many physiological roles in different bacterial systems, recent studies suggest a general role for trans-translation in monitoring protein folding and perhaps other co-translational processes. This review will focus on these new hypotheses and the data that support them.

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