Current Prophylactic Perioperative Antibiotic Guidelines in Trauma: a Review of the Literature and Outcome Data

Overview

Journal Bosn J Basic Med Sci

Specialty General Medicine

Date 2009 Nov 17

PMID 19912119

Citations 4

Authors

Lejla Hadzikadic-Gusic

Lejla Hadzikadic

Suresh Agarwal

Affiliations

Soon will be listed here.

Abstract

A comprehensive review of prophylactic use of perioperative antibiotics in trauma from the 1970s to the present was performed. Evidence based guidelines were used to analyze the data from the past 32 years and define standards of care in the field. Recommendations and suggestions are provided to offer guidelines for prophylactic antibiotic use in trauma. Highlighted topics include general trauma surgery, with focus placed on abdominal and thoracic surgery in trauma, and non-trauma surgery, including subspecialties, for comparison.

Citing Articles

Current status of initial antibiotic therapy and analysis of infections in patients with solitary abdominal trauma: a multicenter trial in Korea.

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Early infectious outcomes after addition of fluoroquinolone or aminoglycoside to posttrauma antibiotic prophylaxis in combat-related open fracture injuries.

Lloyd B, Murray C, Shaikh F, Carson M, Blyth D, Schnaubelt E J Trauma Acute Care Surg. 2017; 83(5):854-861.

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Variation in Postinjury Antibiotic Prophylaxis Patterns Over Five Years in a Combat Zone.

Lloyd B, Murray C, Bradley W, Shaikh F, Aggarwal D, Carson M Mil Med. 2017; 182(S1):346-352.

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Adherence to published antimicrobial prophylaxis guidelines for wounded service members in the ongoing conflicts in Southwest Asia.

Lloyd B, Weintrob A, Hinkle M, Fortuna G, Murray C, Bradley W Mil Med. 2014; 179(3):324-8.

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References

Pronovost P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S . An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med. 2006; 355(26):2725-32. DOI: 10.1056/NEJMoa061115. View

Fabian T, Hoefling S, Strom P, Stone H . Use of antibiotic prophylaxis in penetrating abdominal trauma. Clin Ther. 1982; 5 Suppl A:38-47. View

Luchette F, Barrie P, Oswanski M, Spain D, Mullins C, Palumbo F . Practice Management Guidelines for Prophylactic Antibiotic Use in Tube Thoracostomy for Traumatic Hemopneumothorax: the EAST Practice Management Guidelines Work Group. Eastern Association for Trauma. J Trauma. 2000; 48(4):753-7. DOI: 10.1097/00005373-200004000-00027. View

Sawyer R, Raymond D, Pelletier S, Crabtree T, Gleason T, Pruett T . Implications of 2,457 consecutive surgical infections entering year 2000. Ann Surg. 2001; 233(6):867-74. PMC: 1421331. DOI: 10.1097/00000658-200106000-00018. View

Raymond D, Pelletier S, Crabtree T, Gleason T, Hamm L, Pruett T . Impact of a rotating empiric antibiotic schedule on infectious mortality in an intensive care unit. Crit Care Med. 2001; 29(6):1101-8. DOI: 10.1097/00003246-200106000-00001. View

Reed 2nd R, Ericsson C, Wu A, Fischer R . The pharmacokinetics of prophylactic antibiotics in trauma. J Trauma. 1992; 32(1):21-7. DOI: 10.1097/00005373-199201000-00005. View

Cushing R . Antibiotics in trauma. Surg Clin North Am. 1977; 57(1):165-77. DOI: 10.1016/s0039-6109(16)41141-2. View

. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control. 2004; 32(8):470-85. DOI: 10.1016/S0196655304005425. View

Mandal A, Montano J, Thadepalli H . Prophylactic antibiotics and no antibiotics compared in penetrating chest trauma. J Trauma. 1985; 25(7):639-43. DOI: 10.1097/00005373-198507000-00011. View

10.

Clayman G, Raad I, Hankins P, Weber R . Bacteriologic profile of surgical infection after antibiotic prophylaxis. Head Neck. 1993; 15(6):526-31. DOI: 10.1002/hed.2880150609. View

11.

Lansford T, Moncure M, Carlton E, Endress R, Shik N, Udobi K . Efficacy of a pneumonia prevention protocol in the reduction of ventilator-associated pneumonia in trauma patients. Surg Infect (Larchmt). 2007; 8(5):505-10. DOI: 10.1089/sur.2006.001. View

12.

Hoth J, Franklin G, Stassen N, Girard S, Rodriguez R, Rodriguez J . Prophylactic antibiotics adversely affect nosocomial pneumonia in trauma patients. J Trauma. 2003; 55(2):249-54. DOI: 10.1097/01.TA.0000083334.93868.65. View

13.

Weigelt J, Easley S, Thal E, Palmer L, Newman V . Abdominal surgical wound infection is lowered with improved perioperative enterococcus and bacteroides therapy. J Trauma. 1993; 34(4):579-84; discussion 584-5. DOI: 10.1097/00005373-199304000-00016. View

14.

Eren S, Esme H, Sehitogullari A, Durkan A . The risk factors and management of posttraumatic empyema in trauma patients. Injury. 2007; 39(1):44-9. DOI: 10.1016/j.injury.2007.06.001. View

15.

Holzheimer R . Re: should we use routinely prophylactic antibiotics in patients with chest trauma?. World J Surg. 2006; 30(11):2080-1. DOI: 10.1007/s00268-006-0394-9. View

16.

Allen M . Perioperative antibiotics: when, why?. Thorac Surg Clin. 2005; 15(2):229-35, vi. DOI: 10.1016/j.thorsurg.2005.01.005. View

17.

Ericsson C, Fischer R, Rowlands B, Hunt C, Reed 2nd L . Prophylactic antibiotics in trauma: the hazards of underdosing. J Trauma. 1989; 29(10):1356-61. View

18.

Alexander J . Prophylactic antibiotics in trauma. Am Surg. 1982; 48(2):45-8. View

19.

Velmahos G, Jindal A, Chan L, Kritikos E, Vassiliu P, Berne T . Prophylactic antibiotics after severe trauma: more is not better. Int Surg. 2002; 86(3):176-83. View

20.

Hofstetter S, Pachter H, Bailey A, Coppa G . A prospective comparison of two regimens of prophylactic antibiotics in abdominal trauma: cefoxitin versus triple drug. J Trauma. 1984; 24(4):307-10. DOI: 10.1097/00005373-198404000-00004. View