Advances in Early Kidney Specification, Development and Patterning

Overview

Journal Development

Specialty Biology

Date 2009 Nov 13

PMID 19906853

Citations 168

Authors

Gregory R Dressler

Affiliations

Soon will be listed here.

Abstract

The kidney is a model developmental system for understanding mesodermal patterning and organogenesis, a process that requires regional specification along multiple body axes, the proliferation and differentiation of progenitor cells, and integration with other tissues. Recent progress in the field has highlighted the essential roles of intrinsic nuclear factors and secreted signaling molecules in specifying renal epithelial stem cells and their self-renewal, in driving the complex dynamics of epithelial cell branching morphogenesis, and in nephron patterning. How these developments influence and advance our understanding of kidney development is discussed.

Citing Articles

Expression of ENL YEATS domain tumor mutations in nephrogenic or stromal lineage impairs kidney development.

Xue Z, Xuan H, Lau K, Su Y, Wegener M, Li K Nat Commun. 2025; 16(1):2531.

PMID: 40087269 DOI: 10.1038/s41467-025-57926-z.

Comparative analysis of mesonephric transcriptomics: Conservation of the developmental lineage of nephron stages.

Corkins M, Romero A, Romero-Mora A, Achieng M, Lindstrom N, Lindstrom N bioRxiv. 2025; .

PMID: 39868253 PMC: 11760729. DOI: 10.1101/2025.01.13.632850.

Pathophysiology of Congenital Anomalies of the Kidney and Urinary Tract: A Comprehensive Review.

Brockwell M, Hergenrother S, Satariano M, Shah R, Raina R Cells. 2024; 13(22).

PMID: 39594614 PMC: 11593116. DOI: 10.3390/cells13221866.

Depot-specific mRNA expression programs in human adipocytes suggest physiological specialization via distinct developmental programs.

Clemons H, Hogan D, Brown P PLoS One. 2024; 19(10):e0311751.

PMID: 39401200 PMC: 11472956. DOI: 10.1371/journal.pone.0311751.

Deciphering the cellular and molecular landscapes of Wnt/β-catenin signaling in mouse embryonic kidney development.

Zhao H, Gong H, Zhu P, Sun C, Sun W, Zhou Y Comput Struct Biotechnol J. 2024; 23:3368-3378.

PMID: 39310276 PMC: 11416353. DOI: 10.1016/j.csbj.2024.08.025.

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