» Articles » PMID: 19897078

Ethanol Alters the Physiology of Neuron-glia Communication

Overview
Date 2009 Nov 10
PMID 19897078
Citations 8
Authors
Affiliations
Soon will be listed here.
Abstract

In the central nervous system (CNS), both neurones and astrocytes play crucial roles. On a cellular level, brain activity involves continuous interactions within complex cellular circuits established between neural cells and glia. Although it was initially considered that neurones were the major cell type in cerebral function, nowadays astrocytes are considered to contribute to cerebral function too. Astrocytes support normal neuronal activity, including synaptic function, by regulating the extracellular environment with respect to ions and neurotransmitters. There is a plethora of noxious agents which can lead to the development of alterations in organs and functional systems, and that will end in a chronic prognosis. Among the potentially harmful external agents we can find ethanol consumption, whose consequences have been recognized as a major public health concern. Deregulation of cell cycle has devastating effects on the integrity of cells, and has been closely associated with the development of pathologies which can lead to dysfunction and cell death. An alteration of normal neuronal-glial physiology could represent the basis of neurodegenerative processes. In this review we will pay attention on to the recent findings in astrocyte function and their role toward neurons under ethanol consumption.

Citing Articles

Hemichannels contribute to mitochondrial Ca and morphology alterations evoked by ethanol in astrocytes.

Alvear T, Farias-Pasten A, Vergara S, Prieto-Villalobos J, Silva-Contreras A, Fuenzalida F Front Cell Dev Biol. 2024; 12:1434381.

PMID: 39129788 PMC: 11310047. DOI: 10.3389/fcell.2024.1434381.


Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage.

Gomez G, Alvear T, Roa D, Farias-Pasten A, Vergara S, Mellado L Biol Res. 2024; 57(1):15.

PMID: 38576018 PMC: 10996276. DOI: 10.1186/s40659-024-00493-2.


Cytosolic phospholipase A2 regulates alcohol-mediated astrocyte inflammatory responses in HIV-associated neurocognitive disorders.

Pandey R, Ghorpade A Cell Death Discov. 2016; 1:15045.

PMID: 27551474 PMC: 4979440. DOI: 10.1038/cddiscovery.2015.45.


Chronic alcohol exposure affects the cell components involved in membrane traffic in neuronal dendrites.

Romero A, Renau-Piqueras J, Marin M, Esteban-Pretel G Neurotox Res. 2014; 27(1):43-54.

PMID: 25022897 DOI: 10.1007/s12640-014-9484-x.


Chronic alcohol alters dendritic spine development in neurons in primary culture.

Romero A, Renau-Piqueras J, Marin M, Timoneda J, Berciano M, Lafarga M Neurotox Res. 2013; 24(4):532-48.

PMID: 23820986 DOI: 10.1007/s12640-013-9409-0.