WNK Kinases and Blood Pressure Control

Overview

Journal Curr Hypertens Rep

Specialty Cardiology & Vascular Diseases

Date 2009 Nov 10

PMID 19895753

Citations 8

Authors

Staci L Deaton

Samarpita Sengupta

Melanie H Cobb

Affiliations

Soon will be listed here.

Abstract

The WNK (With No K-Lysine) family of proteins is widely expressed and has been shown to promote blood pressure homeostasis through a variety of mechanisms. Members of this family have been reported to affect sodium/chloride cotransporters, sodium/potassium/chloride cotransporters, potassium/chloride cotransporters, the renal outer medullary potassium channel, and the epithelial sodium channel, directly and indirectly. Mutations in WNK1 and WNK4 were shown to cause pseudohypoaldosteronism type II, a Mendelian disorder characterized by hypertension, hyperkalemia, and acidosis. Because of the complexity of the renal system, it has been difficult to completely define the role of these kinases in kidney function. This article reviews current knowledge of the role of these proteins in ion homeostasis and volume control.

Citing Articles

Unanticipated domain requirements for Drosophila Wnk kinase in vivo.

Yarikipati P, Jonusaite S, Pleinis J, Dominicci Cotto C, Sanchez-Hernandez D, Morrison D PLoS Genet. 2023; 19(10):e1010975.

PMID: 37819975 PMC: 10593226. DOI: 10.1371/journal.pgen.1010975.

Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis.

Mayes-Hopfinger L, Enache A, Xie J, Huang C, Kochl R, Tybulewicz V Nat Commun. 2021; 12(1):4546.

PMID: 34315884 PMC: 8316491. DOI: 10.1038/s41467-021-24784-4.

Hypertension: the missing WNKs.

Dbouk H, Huang C, Cobb M Am J Physiol Renal Physiol. 2016; 311(1):F16-27.

PMID: 27009339 PMC: 4967160. DOI: 10.1152/ajprenal.00358.2015.

Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke.

Begum G, Yuan H, Kahle K, Li L, Wang S, Shi Y Stroke. 2015; 46(7):1956-1965.

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Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.

Dbouk H, Weil L, Perera G, Dellinger M, Pearson G, Brekken R Proc Natl Acad Sci U S A. 2014; 111(45):15999-6004.

PMID: 25362046 PMC: 4234555. DOI: 10.1073/pnas.1419057111.

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