Short Communication: Methamphetamine Treatment Increases in Vitro and in Vivo HIV Replication

Overview

Journal AIDS Res Hum Retroviruses

Publisher Mary Ann Liebert

Specialty Infectious Diseases

Date 2009 Nov 10

PMID 19895343

Citations 42

Authors

Sima Shelly Toussi

Aviva Joseph

Jian Hua Zheng

Monica Dutta

Laura Santambrogio

Harris Goldstein

Affiliations

Soon will be listed here.

Abstract

To delineate the mechanistic basis for the epidemiological association between methamphetamine use and accelerated progression to AIDS, we evaluated the direct in vitro and in vivo effects of methamphetamine on HIV-1 replication. Methamphetamine administration significantly increased HIV-1 production by both HIV-infected monocytes and CD4 T lymphocytes in vitro. In addition, in vivo methamphetamine treatment increased HIV production and viremia in mice transgenic for a replication-competent HIV provirus and human cyclin T1. Methamphetamine activated transcription of the HIV long terminal repeat (LTR) regulatory region, was associated with nuclear translocation of NF-kappaB. Our results provide further insights into the mechanisms by which methamphetamine accelerates disease course in HIV-infected individuals.

Citing Articles

Construction of a Macrophage-Tropic Subtype C HIV-1-mGreenLantern Reporter Virus for Studies on HIV-1 Replication and the Impact of Methamphetamine.

Mofed D, Mandarino A, Wu X, Lang Y, Gowripalan A, Kalpana G Viruses. 2025; 16(12.

PMID: 39772169 PMC: 11680207. DOI: 10.3390/v16121859.

Impact of HIV-1 tat protein on methamphetamine-induced inhibition of vesicular monoamine transporter2-mediated dopamine transport and methamphetamine conditioned place preference in HIV-1 tat transgenic mice.

Zhu J, Cirincione A, Strauss M, Davis S, Eans S, Tribbitt D Eur J Pharmacol. 2024; 984:177030.

PMID: 39366503 PMC: 11563864. DOI: 10.1016/j.ejphar.2024.177030.

HIV-1 and methamphetamine co-treatment in primary human astrocytes: TAARgeting ER/UPR dysfunction.

Proulx J, Park I, Borgmann K NeuroImmune Pharm Ther. 2024; 3(2):139-154.

PMID: 39175523 PMC: 11338011. DOI: 10.1515/nipt-2023-0020.

Astrocytes: Role in pathogenesis and effect of commonly misused drugs in the HIV infected brain.

Pla-Tenorio J, Roig A, Garcia-Cesani P, Santiago L, Sepulveda-Orengo M, Noel Jr R Curr Res Neurobiol. 2023; 5:100108.

PMID: 38020814 PMC: 10663134. DOI: 10.1016/j.crneur.2023.100108.

HIV and Drug Use: A Tale of Synergy in Pulmonary Vascular Disease Development.

Cook C, Craddock V, Ram A, Abraham A, Dhillon N Compr Physiol. 2023; 13(3):4659-4683.

PMID: 37358518 PMC: 10693986. DOI: 10.1002/cphy.c210049.

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