Therapeutic Effect of Caffeic Acid Phenethyl Ester on Cerulein-induced Acute Pancreatitis

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2009 Nov 6

PMID 19891017

Citations 10

Authors

Mehmet Buyukberber

M Cemil Savas

Cahit Bagci

Mehmet Koruk

Murat T Gulsen

Ediz Tutar

Tugba Bilgic

Nurdan O Ceylan

Affiliations

Soon will be listed here.

Abstract

Aim: To evaluate the therapeutic role of caffeic acid phenethyl ester (CAPE) in a rat model of cerulean-induced acute pancreatitis (AP).

Methods: Seventy male Wistar albino rats were divided into seven groups. Acute edematous pancreatitis was induced by subcutaneous cerulein injection (20 microg/kg) four times at 1-h intervals. CAPE (30 mg/kg) was given by subcutaneous injection at the beginning (CAPE 1 group) and 12 h after the last cerulein injection (CAPE 2 group). Serum amylase, lipase, white blood cell count, and tumor necrosis factor (TNF)-alpha levels were measured, and pancreatic histopathology was assessed.

Results: In the AP group, amylase and lipase levels were found to be elevated and the histopathological evaluation showed massive edema and inflammation of the pancreas, with less fatty necrosis when compared with sham and control groups. Amylase and lipase levels and edema formation decreased significantly in the CAPE therapy groups (P < 0001); especially in the CAPE 2 group, edema was improved nearly completely (P = 0001). Inflammation and fatty necrosis were partially recovered by CAPE treatment. The pathological results and amylase level in the placebo groups were similar to those in the AP group. White blood cell count and TNF-alpha concentration was nearly the same in the CAPE and placebo groups.

Conclusion: CAPE may be useful agent in treatment of AP but more experimental and clinical studies are needed to support our observation of beneficial effects of CAPE before clinical usage of this agent.

Citing Articles

Research Progress of Antioxidant Nanomaterials for Acute Pancreatitis.

Zheng X, Zhao J, Wang S, Hu L Molecules. 2022; 27(21).

PMID: 36364064 PMC: 9658789. DOI: 10.3390/molecules27217238.

Golimumab Ameliorates Pancreatic Inflammatory Response in the Cerulein-Induced Acute Pancreatitis in Rats.

Kaplan M, Tanoglu A, Cakir Guney B, Yeniceri M, Cirak Z, Tastan Y Turk J Gastroenterol. 2022; 33(11):918-924.

PMID: 36262104 PMC: 9797786. DOI: 10.5152/tjg.2022.21456.

A Nano-Liposomal Formulation of Caffeic Acid Phenethyl Ester Modulates Nrf2 and NF-κβ Signaling and Alleviates Experimentally Induced Acute Pancreatitis in a Rat Model.

Shahin N, Shamma R, Ahmed I Antioxidants (Basel). 2022; 11(8).

PMID: 36009255 PMC: 9405210. DOI: 10.3390/antiox11081536.

Role of inflammation and oxidative stress in tissue damage associated with cystic fibrosis: CAPE as a future therapeutic strategy.

Soares V, do Carmo T, Dos Anjos F, Wruck J, Maciel S, Bagatini M Mol Cell Biochem. 2021; 477(1):39-51.

PMID: 34529223 DOI: 10.1007/s11010-021-04263-6.

Drug discovery and formulation development for acute pancreatitis.

Jiang X, Zheng Y, Bao S, Zhang H, Chen R, Yao Q Drug Deliv. 2020; 27(1):1562-1580.

PMID: 33118404 PMC: 7598990. DOI: 10.1080/10717544.2020.1840665.

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