Directed Therapy for Exfoliation Syndrome

Overview

Journal Open Ophthalmol J

Publisher Bentham Open

Specialty Ophthalmology

Date 2009 Nov 6

PMID 19888433

Citations 1

Authors

Allison Angelilli

Robert Ritch

Affiliations

Soon will be listed here.

Abstract

Exfoliation syndrome (XFS) is an age-related disorder of the extracellular matrix that leads the production of abnormal fibrillar material that leads to elevated intraocular pressure and a relatively severe glaucoma. Exfoliation material is deposited in numerous ocular tissues and extraocular organs. XFS is associated with ocular ischemia, cerebrovascular disease, neurodegenerative disease and cardiovascular disease. Current modalities of treatment include intraocular pressure lowering with topical antihypertensives, laser trabeculoplasty and filtration surgery. The disease paradigm for XFS should be expanded to include directed therapy designed specifically to target the underlying disease process. Potential targets include preventing the formation or promoting the depolymerization of exfoliation material. Novel therapies targeting trabecular meshwork may prove particularly useful in the care of exfoliative glaucoma. The systemic and ocular associations of XFS underscore the need for a comprehensive search for neuroprotective agents in its treatment.

Citing Articles

Fibrotic Response of Human Trabecular Meshwork Cells to Transforming Growth Factor-Beta 3 and Autotaxin in Aqueous Humor.

Liu M, Honjo M, Yamagishi R, Igarashi N, Nakamura N, Kurano M Biomolecules. 2022; 12(9).

PMID: 36139071 PMC: 9496180. DOI: 10.3390/biom12091231.

References

Ho S, Dogar G, Wang J, Crean J, Wu Q, Oliver N . Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation syndrome. Br J Ophthalmol. 2005; 89(2):169-73. PMC: 1772498. DOI: 10.1136/bjo.2004.044685. View

Lewis C, Smith A, Kamen B . Receptor-mediated folate uptake is positively regulated by disruption of the actin cytoskeleton. Cancer Res. 1998; 58(14):2952-6. View

Leske M, Heijl A, Hussein M, Bengtsson B, Hyman L, Komaroff E . Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial. Arch Ophthalmol. 2003; 121(1):48-56. DOI: 10.1001/archopht.121.1.48. View

Harasymowycz P, Papamatheakis D, Latina M, De Leon M, Lesk M, Damji K . Selective laser trabeculoplasty (SLT) complicated by intraocular pressure elevation in eyes with heavily pigmented trabecular meshworks. Am J Ophthalmol. 2005; 139(6):1110-3. DOI: 10.1016/j.ajo.2004.11.038. View

Fingert J, Alward W, Kwon Y, Wang K, Streb L, Sheffield V . LOXL1 mutations are associated with exfoliation syndrome in patients from the midwestern United States. Am J Ophthalmol. 2007; 144(6):974-975. DOI: 10.1016/j.ajo.2007.09.034. View

Prince A, Streeten B, Ritch R, Dark A, Sperling M . Preclinical diagnosis of pseudoexfoliation syndrome. Arch Ophthalmol. 1987; 105(8):1076-82. DOI: 10.1001/archopht.1987.01060080078032. View

Yimaz A, Adiguzel U, Tamer L, Yildirim O, Oz O, Vatansever H . Serum oxidant/antioxidant balance in exfoliation syndrome. Clin Exp Ophthalmol. 2005; 33(1):63-6. DOI: 10.1111/j.1442-9071.2005.00944.x. View

Honjo M, Tanihara H, Inatani M, Honda Y, Ogino N, Ueno S . Phacoemulsification, intraocular lens implantation, and trabeculotomy to treat pseudoexfoliation syndrome. J Cataract Refract Surg. 1998; 24(6):781-6. DOI: 10.1016/s0886-3350(98)80131-4. View

Fitzl G, Welt K, Wassilew G, Clemens N, Penka K, Mukke N . The influence of hypoxia on the myocardium of experimentally diabetic rats with and without protection by Ginkgo biloba extract. III: Ultrastructural investigations on mitochondria. Exp Toxicol Pathol. 2001; 52(6):557-68. DOI: 10.1016/S0940-2993(01)80017-8. View

10.

Schlotzer-Schrehardt U, Lommatzsch J, Kuchle M, Konstas A, Naumann G . Matrix metalloproteinases and their inhibitors in aqueous humor of patients with pseudoexfoliation syndrome/glaucoma and primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2003; 44(3):1117-25. DOI: 10.1167/iovs.02-0365. View

11.

Schlotzer-Schrehardt U, Zenkel M, Kuchle M, Sakai L, Naumann G . Role of transforming growth factor-beta1 and its latent form binding protein in pseudoexfoliation syndrome. Exp Eye Res. 2002; 73(6):765-80. DOI: 10.1006/exer.2001.1084. View

12.

Oleggini R, Gastaldo N, Di Donato A . Regulation of elastin promoter by lysyl oxidase and growth factors: cross control of lysyl oxidase on TGF-beta1 effects. Matrix Biol. 2007; 26(6):494-505. DOI: 10.1016/j.matbio.2007.02.003. View

13.

Ritch R, Schlotzer-Schrehardt U, Konstas A . Why is glaucoma associated with exfoliation syndrome?. Prog Retin Eye Res. 2003; 22(3):253-75. DOI: 10.1016/s1350-9462(02)00014-9. View

14.

Kiland J, Miller C, Kim C, Ver Hoeve J, Gabelt B, Peterson J . Effect of H-7 and Lat-B on retinal physiology. Curr Eye Res. 2006; 31(5):441-55. DOI: 10.1080/02713680600672185. View

15.

Sibour G, Finazzo C, Boles Carenini A . Monolateral pseudoexfoliatio capsulae: a study of choroidal blood flow. Acta Ophthalmol Scand Suppl. 1997; (224):13-4. DOI: 10.1111/j.1600-0420.1997.tb00449.x. View

16.

Koca M, Naumann G, Volkholz H . Pseudoexfoliation syndrome. Ocular manifestation of a systemic disorder?. Arch Ophthalmol. 1992; 110(12):1752-6. DOI: 10.1001/archopht.1992.01080240092038. View

17.

Mitchell P, Wang J, Smith W . Association of pseudoexfoliation syndrome with increased vascular risk. Am J Ophthalmol. 1997; 124(5):685-7. DOI: 10.1016/s0002-9394(14)70908-0. View

18.

Konstas A, Kozobolis V, Katsimpris I, Boboridis K, Koukoula S, Jenkins J . Efficacy and safety of latanoprost versus travoprost in exfoliative glaucoma patients. Ophthalmology. 2007; 114(4):653-7. DOI: 10.1016/j.ophtha.2006.07.064. View

19.

Ahlemeyer B, Mowes A, Krieglstein J . Inhibition of serum deprivation- and staurosporine-induced neuronal apoptosis by Ginkgo biloba extract and some of its constituents. Eur J Pharmacol. 1999; 367(2-3):423-30. DOI: 10.1016/s0014-2999(98)00903-0. View

20.

Sabanay I, Tian B, Gabelt B, Geiger B, Kaufman P . Latrunculin B effects on trabecular meshwork and corneal endothelial morphology in monkeys. Exp Eye Res. 2005; 82(2):236-46. DOI: 10.1016/j.exer.2005.06.017. View