High Local Concentration: a Fundamental Strategy of Life

Overview

Journal J Mol Biol

Publisher Elsevier

Specialties Microbiology
Molecular Biology

Date 2009 Nov 4

PMID 19883663

Citations 28

Authors

Stefan Oehler

Benno Muller-Hill

Affiliations

Soon will be listed here.

Abstract

Local increase in concentration is a basic principle of transcriptional control. Closer inspection reveals that it is a major force governing all interactions within and between proteins and DNA. Local increase in concentration acts on all levels of organization of living matter. The structures and functions of two central molecules of life-the linear polymers DNA and protein-are particularly illuminating examples. Local increase in concentration leads to cooperative or competitive interactions between molecules. It is an important principle of life.

Citing Articles

Engineered transcription activator-like effector dimer proteins confer DNA loop-dependent gene repression comparable to Lac repressor.

Becker N, Peters J, Lewis E, Daby C, Clark K, Maher 3rd L Nucleic Acids Res. 2024; 52(16):9996-10004.

PMID: 39077947 PMC: 11381355. DOI: 10.1093/nar/gkae656.

Multiple Layered Control of the Conjugation Process of the Plasmid pLS20.

Meijer W, Boer D, Ares S, Alfonso C, Rojo F, Luque-Ortega J Front Mol Biosci. 2021; 8:648468.

PMID: 33816561 PMC: 8014075. DOI: 10.3389/fmolb.2021.648468.

Mechanical Flexibility of DNA: A Quintessential Tool for DNA Nanotechnology.

Saran R, Wang Y, Li I Sensors (Basel). 2020; 20(24).

PMID: 33302459 PMC: 7764255. DOI: 10.3390/s20247019.

Characterization of Gene Repression by Designed Transcription Activator-like Effector Dimer Proteins.

Becker N, Peters J, Schwab T, Phillips W, Wallace J, Clark K Biophys J. 2020; 119(10):2045-2054.

PMID: 33091377 PMC: 7732741. DOI: 10.1016/j.bpj.2020.10.007.

Tuning the catalytic properties of P22 nanoreactors through compositional control.

Sharma J, Douglas T Nanoscale. 2019; 12(1):336-346.

PMID: 31825057 PMC: 8859858. DOI: 10.1039/c9nr08348k.