Genomic Sequence and Organization of Two Members of a Human Lectin Gene Family

Overview

Journal Biochemistry

Specialty Biochemistry

Date 1991 Jan 8

PMID 1988031

Citations 10

Authors

M A Gitt

S H Barondes

Affiliations

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Abstract

We have isolated and sequenced the genomic DNA encoding a human dimeric soluble lactose-binding lectin. The gene has four exons, and its upstream region contains sequences that suggest control by glucocorticoids, heat (environmental) shock, metals, and other factors. We have also isolated and sequenced three exons of the gene encoding another human putative lectin, the existence of which was first indicated by isolation of its cDNA. Comparisons suggest a general pattern of genomic organization of members of this lectin gene family.

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