Primary Therapy for Early-stage Cervical Cancer: Radical Hysterectomy Vs Radiation

Overview

Journal Am J Obstet Gynecol

Publisher Elsevier

Specialty Gynecology & Obstetrics

Date 2009 Nov 3

PMID 19879394

Citations 45

Authors

Nisha Bansal

Thomas J Herzog

Richard E Shaw

William M Burke

Israel Deutsch

Jason D Wright

Affiliations

Soon will be listed here.

Abstract

Objective: We compared survival for women with early-stage cervical cancer who were treated with primary radiation or radical hysterectomy.

Study Design: Patients in the Surveillance, Epidemiology, and End Results database with stage IB1-IIA cervical cancer were examined. Radical hysterectomy was compared with primary combination external-beam and brachytherapy radiation.

Results: A total of 4885 patients were identified. Multivariate analysis showed that radical hysterectomy was associated with a 59% reduction in mortality rate (hazard ratio, 0.41; 95% confidence interval [CI], 0.35-0.50). After stratification by tumor size, hysterectomy was associated with a 62% reduction in mortality rate (hazard ratio, 0.38; 95% CI, 0.30-0.48) for tumors that were <4 cm in diameter and a 49% improvement in survival (hazard ratio, 0.51; 95% CI, 0.36-0.72) for tumors that were 4-6 cm in diameter. Among women with tumors that were >6 cm in size, survival was equivalent between radical hysterectomy and radiation.

Conclusion: Our data indicate that, in women with cervical cancer lesions of <6 cm, radical hysterectomy is superior to primary radiation.

Citing Articles

The Polish Society of Gynecological Oncology Guidelines for the Diagnosis and Treatment of Cervical Cancer (v2024.0).

Sznurkowski J, Bodnar L, Szylberg L, Zolciak-Siwinska A, Danska-Bidzinska A, Klasa-Mazurkiewicz D J Clin Med. 2024; 13(15).

PMID: 39124620 PMC: 11313441. DOI: 10.3390/jcm13154351.

Mexican consensus about surgical treatment in early-stage cervicouterine cancer.

Najera-Munoz C, Hernandez-Romero R, Isla-Ortiz D, Salcedo-Hernandez R Front Oncol. 2024; 14:1385887.

PMID: 38962267 PMC: 11220228. DOI: 10.3389/fonc.2024.1385887.

Investigating the Use of a Liquid Immunogenic Fiducial Eluter Biomaterial in Cervical Cancer Treatment.

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Adapting a model of cervical carcinogenesis to self-identified Black women to evaluate racial disparities in the United States.

Spencer J, Burger E, Campos N, Regan M, Sy S, Kim J J Natl Cancer Inst Monogr. 2023; 2023(62):188-195.

PMID: 37947333 PMC: 10637021. DOI: 10.1093/jncimonographs/lgad015.

Comparison of Oncologic Outcomes between Radical Hysterectomy and Primary Concurrent Chemoradiotherapy in Women with Bulky IB and IIA Cervical Cancer under Risk Stratification.

Chen C, Huang E Cancers (Basel). 2023; 15(11).

PMID: 37296994 PMC: 10252013. DOI: 10.3390/cancers15113034.