The Placenta in the Integrated Physiology of Fetal Volume Control

Overview

Journal Int J Dev Biol

Specialties Biology
Reproductive Medicine

Date 2009 Oct 31

PMID 19876827

Citations 6

Authors

J Job Faber

Debra F Anderson

Affiliations

Soon will be listed here.

Abstract

Almost all water that enters the conceptus of the sheep enters via the placenta. The forces that drive water are hydrostatic and osmotic. The placental channels that allow water to cross into the fetus have not been identified by microanatomic means. Although an "equivalent pore" system can account for the diffusional entry of small hydrophilic solutes, it can be calculated that the filtration coefficient of this system is too small to account for the demonstrated trans-placental water flows. It is possible that a second much less numerous system of large pores permits the flow of water, but that is by no means certain. The placenta does not control the amount of water that enters the conceptus; nor does any other single fetal structure. And water entry is not dependent on the volume of water already present. However, the combined physiological properties of the fetal heart, kidneys, somatic tissues and placenta constitute a consistent explanation of fetal water volume control.

Citing Articles

Nutritional and Physiological Regulation of Water Transport in the Conceptus.

Zhu C, Jiang Z, Johnson G, Burghardt R, Bazer F, Wu G Adv Exp Med Biol. 2021; 1354:109-125.

PMID: 34807439 DOI: 10.1007/978-3-030-85686-1_6.

Arterio-venous fetoplacental vascular geometry and hemodynamics in the mouse placenta.

Rennie M, Cahill L, Adamson S, Sled J Placenta. 2017; 58:46-51.

PMID: 28962695 PMC: 5679460. DOI: 10.1016/j.placenta.2017.08.007.

Ovine uterine space restriction causes dysregulation of the renin-angiotensin system in fetal kidneys.

Kranch-Shorthouse R, Bauer A, Magness R, Lopez G, Segar J, Blohowiak S Biol Reprod. 2017; 96(1):211-220.

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The kidney transcriptome and proteome defined by transcriptomics and antibody-based profiling.

Habuka M, Fagerberg L, Hallstrom B, Kampf C, Edlund K, Sivertsson A PLoS One. 2015; 9(12):e116125.

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An observational study of associations among maternal fluids during parturition, neonatal output, and breastfed newborn weight loss.

Noel-Weiss J, Woodend A, Peterson W, Gibb W, Groll D Int Breastfeed J. 2011; 6:9.

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References

Anderson D, Faber J . Water flux due to colloid osmotic pressures across the haemochorial placenta of the guinea-pig. J Physiol. 1982; 332:521-7. PMC: 1197413. DOI: 10.1113/jphysiol.1982.sp014428. View

Adamson S, Morrow R, Bull S, Langille B . Vasomotor responses of the umbilical circulation in fetal sheep. Am J Physiol. 1989; 256(5 Pt 2):R1056-62. DOI: 10.1152/ajpregu.1989.256.5.R1056. View

Pinson C, Morton M, Thornburg K . Mild pressure loading alters right ventricular function in fetal sheep. Circ Res. 1991; 68(4):947-57. DOI: 10.1161/01.res.68.4.947. View

Giraud G, Faber J, Jonker S, Davis L, Anderson D . Intravascular infusions of plasma into fetal sheep cause arterial and venous hypertension. J Appl Physiol (1985). 2005; 99(3):884-9. DOI: 10.1152/japplphysiol.01429.2004. View

Thornburg K, Burry K, Adams A, Kirk E, Faber J . Permeability of placenta to inulin. Am J Obstet Gynecol. 1988; 158(5):1165-9. DOI: 10.1016/0002-9378(88)90246-3. View

Davis L, Hohimer A . Hemodynamics and organ blood flow in fetal sheep subjected to chronic anemia. Am J Physiol. 1991; 261(6 Pt 2):R1542-8. DOI: 10.1152/ajpregu.1991.261.6.R1542. View

Faber J . Filtration and diffusion across the immature placenta of the anaesthetized rat embryo. Placenta. 1999; 20(4):331-7. DOI: 10.1053/plac.1998.0382. View

Thornburg K, Morton M . Filling and arterial pressures as determinants of left ventricular stroke volume in fetal lambs. Am J Physiol. 1986; 251(5 Pt 2):H961-8. DOI: 10.1152/ajpheart.1986.251.5.H961. View

Faber J . Transplacental clearances of inert hydrophilic tracers in rabbits of 18 days gestation. Placenta. 1995; 16(5):403-12. DOI: 10.1016/0143-4004(95)90099-3. View

10.

Boyd R, Haworth C, Stacey T, Ward H . Permeability of the sheep placenta to unmetabolized polar non-electrolytes. J Physiol. 1976; 256(3):617-34. PMC: 1309328. DOI: 10.1113/jphysiol.1976.sp011342. View

11.

Anderson D, Borst N, Boyd R, Faber J . Filtration of water from mother to conceptus via paths independent of fetal placental circulation in sheep. J Physiol. 1990; 431:1-10. PMC: 1181761. DOI: 10.1113/jphysiol.1990.sp018317. View

12.

Faber J, Anderson D . Concentrations of Na+ and Cl- in transplacental ultrafiltrate in sheep. J Physiol. 1995; 487(1):159-67. PMC: 1156606. DOI: 10.1113/jphysiol.1995.sp020868. View

13.

Armentrout T, Katz S, Thornburg K, Faber J . Osmotic flow through the placental barrier of chronically prepared sheep. Am J Physiol. 1977; 233(4):H466-74. DOI: 10.1152/ajpheart.1977.233.4.H466. View

14.

Faber J, Anderson D . Model study of placental water transfer and causes of fetal water disease in sheep. Am J Physiol. 1990; 258(5 Pt 2):R1257-70. DOI: 10.1152/ajpregu.1990.258.5.R1257. View

15.

Faber J, Anderson D . Hydrops fetalis in nephrectomized fetal lambs infused with angiotensin I. Am J Physiol. 1994; 267(6 Pt 2):R1522-7. DOI: 10.1152/ajpregu.1994.267.6.R1522. View

16.

Powell T, Brace R . Fetal fluid responses to long-term 5 M NaCl infusion: where does all the salt go?. Am J Physiol. 1991; 261(2 Pt 2):R412-9. DOI: 10.1152/ajpregu.1991.261.2.R412. View

17.

Faber J, Anderson D, Jonker S, Davis L, Giraud G . Fetal infusions of plasma cause an increase in umbilical vascular resistance in sheep. Placenta. 2005; 27(8):876-81. DOI: 10.1016/j.placenta.2005.09.003. View

18.

Adamson S, Whiteley K, Langille B . Pulsatile pressure-flow relations and pulse-wave propagation in the umbilical circulation of fetal sheep. Circ Res. 1992; 70(4):761-72. DOI: 10.1161/01.res.70.4.761. View

19.

Thornburg K, Faber J . Transfer of hydrophilic molecules by placenta and yolk sac of the guinea pig. Am J Physiol. 1977; 233(3):C111-24. DOI: 10.1152/ajpcell.1977.233.3.C111. View

20.

Brace R . Fetal blood volume, urine flow, swallowing, and amniotic fluid volume responses to long-term intravascular infusions of saline. Am J Obstet Gynecol. 1989; 161(4):1049-54. DOI: 10.1016/0002-9378(89)90782-5. View