Hyperpolarized MR Imaging: Neurologic Applications of Hyperpolarized Metabolism

Overview

Journal AJNR Am J Neuroradiol

Specialty Neurology

Date 2009 Oct 31

PMID 19875468

Citations 19

Authors

B D Ross

P Bhattacharya

S Wagner

T Tran

N Sailasuta

Affiliations

Soon will be listed here.

Abstract

Hyperpolarization is the general term for a method of enhancing the spin-polarization difference of populations of nuclei in a magnetic field. No less than 5 distinct techniques (dynamic nuclear polarization [DNP]; parahydrogen-induced polarization-parahydrogen and synthesis allow dramatically enhanced nuclear alignment [PHIP-PASADENA]; xenon/helium polarization transfer; Brute Force; (1)H hyperpolarized water) are currently under exhaustive investigation as means of amplifying the intrinsically (a few parts per million) weak signal intensity used in conventional MR neuroimaging and spectroscopy. HD-MR imaging in vivo is a metabolic imaging tool causing much of the interest in HD-MR imaging. The most successful to date has been DNP, in which carbon-13 ((13)C) pyruvic acid has shown many. PHIP-PASADENA with (13)C succinate has shown HD-MR metabolism in vivo in tumor-bearing mice of several types, entering the Krebs-tricarboxylic acid cycle for ultrafast detection with (13)C MR imaging, MR spectroscopy, and chemical shift imaging. We will discuss 5 promising preclinical studies: (13)C succinate PHIP in brain tumor; (13)C ethylpyruvate DNP and (13)C acetate; DNP in rodent brain; (13)C succinate PHIP versus gadolinium imaging of stroke; and (1)H hyperpolarized imaging. Recent developments in clinical (13)C neurospectroscopy encourage us to overcome the remaining barriers to clinical HD-MR imaging.

Citing Articles

C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI.

Miller J, Grist J, Serres S, Larkin J, Lau A, Ray K Sci Rep. 2018; 8(1):15082.

PMID: 30305655 PMC: 6180068. DOI: 10.1038/s41598-018-33363-5.

Succinate Accumulation Is Associated with a Shift of Mitochondrial Respiratory Control and HIF-1α Upregulation in PTEN Negative Prostate Cancer Cells.

Weber A, Klocker H, Oberacher H, Gnaiger E, Neuwirt H, Sampson N Int J Mol Sci. 2018; 19(7).

PMID: 30037119 PMC: 6073160. DOI: 10.3390/ijms19072129.

Biomolecular MRI reporters: Evolution of new mechanisms.

Mukherjee A, Davis H, Ramesh P, Lu G, Shapiro M Prog Nucl Magn Reson Spectrosc. 2017; 102-103:32-42.

PMID: 29157492 PMC: 5726449. DOI: 10.1016/j.pnmrs.2017.05.002.

A pulse programmable parahydrogen polarizer using a tunable electromagnet and dual channel NMR spectrometer.

Coffey A, Shchepin R, Feng B, Colon R, Wilkens K, Waddell K J Magn Reson. 2017; 284:115-124.

PMID: 29028543 PMC: 5708540. DOI: 10.1016/j.jmr.2017.09.013.

Magnetic resonance imaging with hyperpolarized agents: methods and applications.

Adamson E, Ludwig K, Mummy D, Fain S Phys Med Biol. 2017; 62(13):R81-R123.

PMID: 28384123 PMC: 5730331. DOI: 10.1088/1361-6560/aa6be8.

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