Nonuniform Distribution of DNA Repair in Chromatin After Treatment with Methyl Methanesulfonate

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1977 Aug 1

PMID 198747

Citations 13

Authors

W J Bodell

Affiliations

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Abstract

The distribution of methyl methanesulfonate induced DNA repair was measured in mouse mammary cell chromatin by digestion of "repair labeled" nuclei with micrococcal nuclease. The results indicate that there is a nonuniform distribution of DNA repair in chromatin. The chromatin fraction digested during the first 5 minutes of incubation with micrococcal nuclease appears to be a primary site of DNA repair after methyl methanesulfoante treatment. The observed nonuniform distribution of DNA repair in chromatin may be due to 1)a nonrandom alkylation of DNA in chromatin by methyl methanesulfonate or 2)areas in chromatin of increased accessibility for the repair enzymes to the DNA lesions.

Citing Articles

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Mechanisms of transcription-repair coupling and mutation frequency decline.

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The use of radioimmunoassay to study the formation and disappearance of O6-methylguanine in mouse liver satellite and main-band DNA following dimethylnitrosamine administration.

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Bodell W, Cleaver J Nucleic Acids Res. 1981; 9(1):203-13.

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References

STEVENSON K, CURTIS H . Chromosomal aberrations in irradiated and nitrogen mustard-treated mice. Radiat Res. 1961; 15:774-84. View

Bodell W, BANERJEE M . Reduced DNA repair in mouse satellite DNA after treatment with methylmethanesulfonate, and N-methyl-N-nitrosourea. Nucleic Acids Res. 1976; 3(7):1689-701. PMC: 343028. DOI: 10.1093/nar/3.7.1689. View

Olins A, Olins D . Spheroid chromatin units (v bodies). Science. 1974; 183(4122):330-2. DOI: 10.1126/science.183.4122.330. View

Reeves B, Margoles C . Preferential location of chlorambucil-induced breakage in the chromosomes of normal human lymphocytes. Mutat Res. 1974; 26(3):205-8. DOI: 10.1016/s0027-5107(74)80076-x. View

Natarajan A, AHNSTROM G . The localisation of radiation induced chromosome aberrations in relation to the distribution of heterochromatin in Secale cereale. Chromosoma. 1970; 30(2):250-7. DOI: 10.1007/BF00282004. View

Takebe H, Nii S, Ishii M, Utsumi H . Comparative studies of host-cell reactivation, colony forming ability and excision repair after UV irradiation of xeroderma pigmentosum, normal human and some other mammalian cells. Mutat Res. 1974; 25(3):383-90. DOI: 10.1016/0027-5107(74)90067-0. View

Wheeler K, LETT J . On the possibility that DNA repair is related to age in non-dividing cells. Proc Natl Acad Sci U S A. 1974; 71(5):1862-5. PMC: 388342. DOI: 10.1073/pnas.71.5.1862. View

Axel R, Melchior Jr W, Felsenfeld G . Specific sites of interaction between histones and DNA in chromatin. Proc Natl Acad Sci U S A. 1974; 71(10):4101-5. PMC: 434336. DOI: 10.1073/pnas.71.10.4101. View

Buhl S, Setlow R, Regan J . DNA repair in Potorous tridactylus. Biophys J. 1974; 14(10):791-803. PMC: 1334572. DOI: 10.1016/S0006-3495(74)85949-7. View

10.

KAKUNAGA T . Requirement for cell replication in the fixation and expression of the transformed state in mouse cells treated with 4-nitroquinoline-1-oxide. Int J Cancer. 1974; 14(6):736-42. DOI: 10.1002/ijc.2910140607. View

11.

Noll M . Subunit structure of chromatin. Nature. 1974; 251(5472):249-51. DOI: 10.1038/251249a0. View

12.

Sirover M, Loeb L . Erroneous base-pairing induced by a chemical carcinogen during DNA synthesis. Nature. 1974; 252(5482):414-6. DOI: 10.1038/252414a0. View

13.

Harris C, Connor R, JACKSON F, Lieberman M . Intranuclear distribution of DNA repair synthesis induced by chemical carcinogens or ultraviolet light in human diploid fibroblasts. Cancer Res. 1974; 34(12):3461-8. View

14.

Wilkins R, Hart R . Preferential DNA repair in human cells. Nature. 1974; 247(5435):35-6. DOI: 10.1038/247035a0. View

15.

Kornberg R, Thomas J . Chromatin structure; oligomers of the histones. Science. 1974; 184(4139):865-8. DOI: 10.1126/science.184.4139.865. View

16.

Holmberg M, Jonasson J . Preferential location of x-ray induced chromosome breakage in the R-bands of human chromosomes. Hereditas. 1973; 74(1):57-67. DOI: 10.1111/j.1601-5223.1973.tb01104.x. View

17.

Paterson M, Lohman P, Sluyter M . Use of UV endonuclease from Micrococcus luteus to monitor the progress of DNA repair in UV-irradiated human cells. Mutat Res. 1973; 19(2):245-56. DOI: 10.1016/0027-5107(73)90083-3. View

18.

Massie H, Baird M, Nicolosi R, Samis H . Changes in the structure of rat liver DNA in relation to age. Arch Biochem Biophys. 1972; 153(2):736-41. DOI: 10.1016/0003-9861(72)90392-x. View

19.

CASPERSSON T, Haglund U, Lindell B, ZECH L . Radiation-induced non-random chromosome breakage. Exp Cell Res. 1972; 75(2):541-3. DOI: 10.1016/0014-4827(72)90469-7. View

20.

Lieberman M, Dipple A . Removal of bound carcinogen during DNA repair in nondividing human lymphocytes. Cancer Res. 1972; 32(9):1855-60. View