THE OCCURRENCE AND STRUCTURE OF MICROBODIES : A Comparative Study

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2009 Oct 30

PMID 19866683

Citations 16

Authors

B A Afzelius

Affiliations

Soon will be listed here.

Abstract

Livers from chickens, rats, mongrel dogs, Dalmatian dogs, and man have been examined in the electron microscope in order to compare the microbodies with the known content of uricase. It is concluded that microbodies with inclusion are present in rats, mongrel dogs, and, although the inclusion generally is smaller, in Dalmatian dogs. The inclusion has a characteristic structural appearance. These species (rat, dog) have uricase. Chickens and man lack both the enzyme uricase and the microbody inclusion. This evidence and that from previously published electron micrographs in the literature on microbodies support the notion of a positive correlation between uricase and microbodies with an inclusion. It is recommended that the term "uricosome" be used for such microbodies that have an inclusion of the appearance here described.

Citing Articles

Control by phytochrome of urate oxidase and allantoinase activities during peroxisome development in the cotyledons of mustard (Sinapis alba L.) seedlings.

Hong Y, Schopfer P Planta. 2013; 152(4):325-35.

PMID: 24301027 DOI: 10.1007/BF00388257.

Peroxisomes (microbodies) in human glial tumors. a cytochemical ultrastructural study.

Sima A Acta Neuropathol. 1980; 51(2):113-7.

PMID: 6108044 DOI: 10.1007/BF00690452.

The liver of Myxine glutinosa: a true tubular gland.

Mugnaini E, Harboe S Z Zellforsch Mikrosk Anat. 1967; 78(3):341-69.

PMID: 5598150 DOI: 10.1007/BF00325318.

Cytochemical localization by ferricyanide reduction of -hydroxy acid oxidase activity in peroxisomes of rat kidney.

Shnitka T, Talibi G Histochemie. 1971; 27(2):137-58.

PMID: 5092695 DOI: 10.1007/BF00284956.

Histochemical studies on urate oxidase in several mammals with special reference to uricolytic ability of primates.

Nakajima Y, BOURNE G Histochemie. 1970; 22(1):20-4.

PMID: 4986250 DOI: 10.1007/BF00310545.

References

NOVIKOFF A, Essner E . The liver cell. Some new approaches to its study. Am J Med. 1960; 29:102-31. DOI: 10.1016/0002-9343(60)90011-5. View

Ichida F, Funahashi H . ELECTRON MICROSCOPIC OBSERVATIONS ON LIVER CELLS OF CASES WITH DUBIN-JOHNSON SYNDROME. Acta Hepatosplenol. 1964; 11:332-41. View

ZAHND J, Porte A, Delage J . [Modifications in the ultrastructure of the hepatic cells of certain lower vertebrates in relation to the ovarian cycle and the administration of gynogenic substances]. C R Seances Soc Biol Fil. 1960; 154:1320-3. View

HIFT H, STRAWITZ J . Irreversible hemorrhagic shock in dogs: structure and function of liver mitochondria. Am J Physiol. 1961; 200:264-8. DOI: 10.1152/ajplegacy.1961.200.2.264. View

ALBOT G, JEZEQUEL A, Lunel J . [Cholostatic episodes during the course of jaundice caused by viral hepatitis. Their biological manifestations and their aspect in optical and electron microscopy]. Acta Hepatosplenol. 1962; 9:140-54. View

NORTH R, Pollak J . An electron microscope study on the variation of nuclear-mitochondrial proximity in developing chick liver. J Ultrastruct Res. 1961; 5:497-503. DOI: 10.1016/s0022-5320(61)80023-3. View

OLIVER-PASCUAL E . [The exploration of liver cells with the ultramicroscope and its clinical applications]. Rev Esp Enferm Apar Dig Nutr. 1961; 20:539-43. View

Steiner J, Carruthers J . Studies on the Fine Structure of the Terminal Branches of the Biliary Tree: II. Observations of Pathologically Altered Bile Canaliculi. Am J Pathol. 2009; 39(1):41-63. PMC: 1942385. View

JONES O . De novo origin of the nuclear membrane. Nature. 1960; 188:239-40. DOI: 10.1038/188239a0. View

10.

GUEFT B . Viral hepatitis under the electron microscope. Arch Pathol. 1961; 72:61-9. View

11.

Carruthers J, Steiner J . Experimental extrahepatic biliary obstruction. Fine structural changes of liver cell mitochondria. Gastroenterology. 1962; 42:419-30. View

12.

David H . [PHYSIOLOGIC AND PATHOLOGIC MODIFICATIONS OF THE SUBMICROSCOPIC STRUCTURE. I. KARYOPLASM. NUCLEAR INCLUSIONS]. Z Mikrosk Anat Forsch. 1964; 71:412-56. View

13.

Schaffner F, Sternlieb I, BARKA T, Popper H . Hepatocellular changes in Wilson's disease. Histochemical and electron microscopic studies. Am J Pathol. 1962; 41:315-28. PMC: 1949531. View

14.

COSSEL L . [Electron microscopic findings in liver epithelial cells in virus hepatitis]. Acta Hepatosplenol. 1961; 8:333-56. View

15.

LUFT J . Improvements in epoxy resin embedding methods. J Biophys Biochem Cytol. 1961; 9:409-14. PMC: 2224998. DOI: 10.1083/jcb.9.2.409. View

16.

BETOURNE C, Godeau P, SALOMON J, Badin J, SIGUIER F . [Study by electron microscope of a lymph node and hepatic biopsy in a case of Waldenstrom's macro-globulinemia. Failure of a treatment trial with cystamine]. Bull Mem Soc Med Hop Paris. 1962; 113:300-6. View

17.

DE DUVE C, BEAUFAY H, Jacques P, RAHMAN-LI Y, Sellinger O, WATTIAUX R . Intracellular localization of catalase and of some oxidases in rat liver. Biochim Biophys Acta. 1960; 40:186-7. DOI: 10.1016/0006-3002(60)91338-x. View

18.

JONES O . Origin of megakaryocyte granules from Golgi vesicles. Anat Rec. 1960; 138:105-13. DOI: 10.1002/ar.1091380204. View

19.

COSSEL L . [Electron microscope findings on "inclusion bodies" in the nuclei of human liver epithelial cells]. Z Zellforsch Mikrosk Anat. 1962; 57:512-9. View

20.

Schaffner F, Popper H . Electron microscopic study of human cholestasis. Proc Soc Exp Biol Med. 1959; 101:777-9. DOI: 10.3181/00379727-101-25091. View