Bone Tissue Engineering Therapeutics: Controlled Drug Delivery in Three-dimensional Scaffolds

Overview

Journal J R Soc Interface

Specialties Biology
Biomedical Engineering
Biophysics

Date 2009 Oct 30

PMID 19864265

Citations 105

Authors

Viviana Mourino

Aldo R Boccaccini

Affiliations

Soon will be listed here.

Abstract

This paper provides an extensive overview of published studies on the development and applications of three-dimensional bone tissue engineering (TE) scaffolds with potential capability for the controlled delivery of therapeutic drugs. Typical drugs considered include gentamicin and other antibiotics generally used to combat osteomyelitis, as well as anti-inflammatory drugs and bisphosphonates, but delivery of growth factors is not covered in this review. In each case reviewed, special attention has been given to the technology used for controlling the release of the loaded drugs. The possibility of designing multifunctional three-dimensional bone TE scaffolds for the emerging field of bone TE therapeutics is discussed. A detailed summary of drugs included in three-dimensional scaffolds and the several approaches developed to combine bioceramics with various polymeric biomaterials in composites for drug-delivery systems is included. The main results presented in the literature are discussed and the remaining challenges in the field are summarized with suggestions for future research directions.

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References

Nie L, Nicolau D, Nightingale C, Browner B, Quintiliani R . In vitro elution of ofloxacin from a bioabsorbable polymer. Acta Orthop Scand. 1995; 66(4):365-8. DOI: 10.3109/17453679508995563. View

Chung H, Park T . Surface engineered and drug releasing pre-fabricated scaffolds for tissue engineering. Adv Drug Deliv Rev. 2007; 59(4-5):249-62. DOI: 10.1016/j.addr.2007.03.015. View

Faucheux C, Verron E, Soueidan A, Josse S, Arshad M, Janvier P . Controlled release of bisphosphonate from a calcium phosphate biomaterial inhibits osteoclastic resorption in vitro. J Biomed Mater Res A. 2008; 89(1):46-56. DOI: 10.1002/jbm.a.31989. View

Kawashita M, Tsuneyama S, Miyaji F, Kokubo T, Kozuka H, Yamamoto K . Antibacterial silver-containing silica glass prepared by sol-gel method. Biomaterials. 2000; 21(4):393-8. DOI: 10.1016/s0142-9612(99)00201-x. View

Duarte A, Mano J, Reis R . Dexamethasone-loaded scaffolds prepared by supercritical-assisted phase inversion. Acta Biomater. 2009; 5(6):2054-62. DOI: 10.1016/j.actbio.2009.01.047. View

Gristina A . Biomaterial-centered infection: microbial adhesion versus tissue integration. Science. 1987; 237(4822):1588-95. DOI: 10.1126/science.3629258. View

Nicolau D, Nie L, Tessier P, Kourea H, Nightingale C . Prophylaxis of acute osteomyelitis with absorbable ofloxacin-impregnated beads. Antimicrob Agents Chemother. 1998; 42(4):840-2. PMC: 105552. DOI: 10.1128/AAC.42.4.840. View

Livingston T, Ducheyne P, Garino J . In vivo evaluation of a bioactive scaffold for bone tissue engineering. J Biomed Mater Res. 2002; 62(1):1-13. DOI: 10.1002/jbm.10157. View

Kanellakopoulou K, Giamarellos-Bourboulis E . Carrier systems for the local delivery of antibiotics in bone infections. Drugs. 2000; 59(6):1223-32. DOI: 10.2165/00003495-200059060-00003. View

10.

Saltzman W, Olbricht W . Building drug delivery into tissue engineering. Nat Rev Drug Discov. 2002; 1(3):177-86. DOI: 10.1038/nrd744. View

11.

Joosten U, Joist A, Frebel T, Brandt B, Diederichs S, von Eiff C . Evaluation of an in situ setting injectable calcium phosphate as a new carrier material for gentamicin in the treatment of chronic osteomyelitis: studies in vitro and in vivo. Biomaterials. 2004; 25(18):4287-95. DOI: 10.1016/j.biomaterials.2003.10.083. View

12.

Rodan G, Martin T . Therapeutic approaches to bone diseases. Science. 2000; 289(5484):1508-14. DOI: 10.1126/science.289.5484.1508. View

13.

Prabu P, Dharmaraj N, Aryal S, Lee B, Ramesh V, Kim H . Preparation and drug release activity of scaffolds containing collagen and poly(caprolactone). J Biomed Mater Res A. 2006; 79(1):153-8. DOI: 10.1002/jbm.a.30715. View

14.

Xynos I, Edgar A, Buttery L, Hench L, Polak J . Gene-expression profiling of human osteoblasts following treatment with the ionic products of Bioglass 45S5 dissolution. J Biomed Mater Res. 2001; 55(2):151-7. DOI: 10.1002/1097-4636(200105)55:2<151::aid-jbm1001>3.0.co;2-d. View

15.

Yun H, Kim S, Hyun Y, Heo S, Shin J . Hierarchically mesoporous-macroporous bioactive glasses scaffolds for bone tissue regeneration. J Biomed Mater Res B Appl Biomater. 2008; 87(2):374-80. DOI: 10.1002/jbm.b.31114. View

16.

Han D, Gouma P . Electrospun bioscaffolds that mimic the topology of extracellular matrix. Nanomedicine. 2007; 2(1):37-41. DOI: 10.1016/j.nano.2006.01.002. View

17.

Victor S, Kumar T . BCP ceramic microspheres as drug delivery carriers: synthesis, characterisation and doxycycline release. J Mater Sci Mater Med. 2007; 19(1):283-90. DOI: 10.1007/s10856-006-0044-7. View

18.

Van Beek E, Cohen L, Leroy I, Ebetino F, Lowik C, Papapoulos S . Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates. Bone. 2003; 33(5):805-11. DOI: 10.1016/j.bone.2003.07.007. View

19.

Adams A, Santschi E, Mellencamp M . Antibacterial properties of a silver chloride-coated nylon wound dressing. Vet Surg. 1999; 28(4):219-25. DOI: 10.1053/jvet.1999.0219. View

20.

Wu P, Grainger D . Drug/device combinations for local drug therapies and infection prophylaxis. Biomaterials. 2005; 27(11):2450-67. DOI: 10.1016/j.biomaterials.2005.11.031. View