Angiogenesis in Rheumatoid Arthritis

Overview

Journal Autoimmunity

Specialty Allergy & Immunology

Date 2009 Oct 30

PMID 19863375

Citations 39

Authors

Zoltan Szekanecz

Timea Besenyei

Gyorgy Paragh

Alisa E Koch

Affiliations

Soon will be listed here.

Abstract

Angiogenesis is the formation of new capillaries from pre-existing vessels. A number of soluble and cell-bound factors may stimulate neovascularization. The perpetuation of angiogenesis involving numerous soluble and cell surface-bound mediators has been associated with rheumatoid arthritis (RA). These angiogenic mediators, among others, include growth factors, primarily vascular endothelial growth factor (VEGF) and hypoxia-inducible factors (HIFs), as well as pro-inflammatory cytokines, various chemokines, matrix components, cell adhesion molecules, proteases and others. Among the several potential angiogenesis inhibitors, targeting of VEGF, HIF-1, angiogenic chemokines, tumor necrosis factor-alpha and the alpha(V)beta(3) integrin may attenuate the action of angiogenic mediators and thus synovial angiogenesis. In addition, some naturally produced or synthetic compounds including angiostatin, endostatin, paclitaxel, fumagillin analogues, 2-methoxyestradiol and thalidomide may be included in the management of RA.

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References

Shahrara S, Volin M, Connors M, Haines G, Koch A . Differential expression of the angiogenic Tie receptor family in arthritic and normal synovial tissue. Arthritis Res. 2002; 4(3):201-8. PMC: 111023. DOI: 10.1186/ar407. View

Yin Y, Huang L, Zhao X, Fang Y, Yu S, Zhao J . AMD3100 mobilizes endothelial progenitor cells in mice, but inhibits its biological functions by blocking an autocrine/paracrine regulatory loop of stromal cell derived factor-1 in vitro. J Cardiovasc Pharmacol. 2007; 50(1):61-7. DOI: 10.1097/FJC.0b013e3180587e4d. View

Choi S, Kim J, Seok J, Park Y, Lee S . Therapeutic effect of anti-vascular endothelial growth factor receptor I antibody in the established collagen-induced arthritis mouse model. Clin Rheumatol. 2008; 28(3):333-7. DOI: 10.1007/s10067-008-1075-x. View

Grosios K, Wood J, Esser R, Raychaudhuri A, Dawson J . Angiogenesis inhibition by the novel VEGF receptor tyrosine kinase inhibitor, PTK787/ZK222584, causes significant anti-arthritic effects in models of rheumatoid arthritis. Inflamm Res. 2004; 53(4):133-42. DOI: 10.1007/s00011-003-1230-4. View

Bongartz T, Coras B, Vogt T, Scholmerich J, Muller-Ladner U . Treatment of active psoriatic arthritis with the PPARgamma ligand pioglitazone: an open-label pilot study. Rheumatology (Oxford). 2004; 44(1):126-9. DOI: 10.1093/rheumatology/keh423. View

Komorowski J, Jerczynska H, Siejka A, Baranska P, Lawnicka H, Pawlowska Z . Effect of thalidomide affecting VEGF secretion, cell migration, adhesion and capillary tube formation of human endothelial EA.hy 926 cells. Life Sci. 2005; 78(22):2558-63. DOI: 10.1016/j.lfs.2005.10.016. View

Kurosaka D, Yoshida K, Yasuda J, Yasuda C, Noda K, Furuya K . The effect of endostatin evaluated in an experimental animal model of collagen-induced arthritis. Scand J Rheumatol. 2007; 36(6):434-41. DOI: 10.1080/03009740701605913. View

Nanki T, Hayashida K, El-Gabalawy H, Suson S, Shi K, Girschick H . Stromal cell-derived factor-1-CXC chemokine receptor 4 interactions play a central role in CD4+ T cell accumulation in rheumatoid arthritis synovium. J Immunol. 2000; 165(11):6590-8. DOI: 10.4049/jimmunol.165.11.6590. View

Jacq L, Garnier S, Dieude P, Michou L, Pierlot C, Migliorini P . The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the European Caucasian population: a family-based study. Arthritis Res Ther. 2007; 9(4):R63. PMC: 2206364. DOI: 10.1186/ar2221. View

10.

Dessein P, Joffe B . Suppression of circulating interleukin-6 concentrations is associated with decreased endothelial activation in rheumatoid arthritis. Clin Exp Rheumatol. 2006; 24(2):161-7. View

11.

Giatromanolaki A, Sivridis E, Maltezos E, Athanassou N, Papazoglou D, Gatter K . Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis. Arthritis Res Ther. 2003; 5(4):R193-201. PMC: 165055. DOI: 10.1186/ar756. View

12.

Maurer A, Zhou B, Han Z . Roles of platelet factor 4 in hematopoiesis and angiogenesis. Growth Factors. 2007; 24(4):242-52. DOI: 10.1080/08977190600988225. View

13.

Hannig G, Bernier S, Hoyt J, Doyle B, Clark E, Karp R . Suppression of inflammation and structural damage in experimental arthritis through molecular targeted therapy with PPI-2458. Arthritis Rheum. 2007; 56(3):850-60. DOI: 10.1002/art.22402. View

14.

Szekanecz Z, Koch A . Chemokines and angiogenesis. Curr Opin Rheumatol. 2001; 13(3):202-8. DOI: 10.1097/00002281-200105000-00009. View

15.

Salcedo R, Ponce M, Young H, Wasserman K, Ward J, Kleinman H . Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression. Blood. 2000; 96(1):34-40. View

16.

Shahrara S, Castro-Rueda H, Haines G, Koch A . Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues. Arthritis Res Ther. 2007; 9(5):R112. PMC: 2212559. DOI: 10.1186/ar2318. View

17.

Goedkoop A, Kraan M, Picavet D, de Rie M, Teunissen M, Bos J . Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy: a prospective single-centre study. Arthritis Res Ther. 2004; 6(4):R326-34. PMC: 464872. DOI: 10.1186/ar1182. View

18.

Woods J, Mogollon A, Amin M, Martinez R, Koch A . The role of COX-2 in angiogenesis and rheumatoid arthritis. Exp Mol Pathol. 2003; 74(3):282-90. DOI: 10.1016/s0014-4800(03)00019-4. View

19.

Lee M, Yoo S, Cho C, Suh P, Kim W, Ryu S . Serum amyloid A binding to formyl peptide receptor-like 1 induces synovial hyperplasia and angiogenesis. J Immunol. 2006; 177(8):5585-94. DOI: 10.4049/jimmunol.177.8.5585. View

20.

Morand E, Leech M, Bernhagen J . MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis. Nat Rev Drug Discov. 2006; 5(5):399-410. DOI: 10.1038/nrd2029. View