Replication Intermediates As Substrates for DNA Rearrangements
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Abstract
A model for the formation of DNA rearrangements in somatic cells is presented. Two double-strand breaks at the junctions between unreplicated DNA and newly replicated DNA generate four double-stranded DNA molecules that can recombine to form tandem duplications, inversions, deletions and extrachromosomal DNA circles.
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Deletions at stalled replication forks occur by two different pathways.
Bierne H, Ehrlich S, Michel B EMBO J. 1997; 16(11):3332-40.
PMID: 9214648 PMC: 1169949. DOI: 10.1093/emboj/16.11.3332.