Induction of Growth Arrest by a Temperature-sensitive P53 Mutant is Correlated with Increased Nuclear Localization and Decreased Stability of the Protein

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 1991 Jan 1

PMID 1986251

Citations 41

Authors

D Ginsberg

M Oren

Affiliations

Soon will be listed here.

Abstract

A temperature-sensitive mutant of p53, p53Val-135, was found to be able to arrest cell proliferation when overexpressed at 32.5 degrees C. While much of the protein was cytoplasmic in cells proliferating at 37.5 degrees C, it became predominantly nuclear at 32.5 degrees C. Concomitantly, p53Val-135 became destabilized, although not to the extent seen in primary fibroblasts.

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