Appearance of Peripheral Blood Plasma Cells and Memory B Cells in a Primary and Secondary Immune Response in Humans

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2009 Oct 22

PMID 19843885

Citations 66

Authors

Geraldine Blanchard-Rohner

Anoop S Pulickal

Cornelia M Jol-van der Zijde

Matthew D Snape

Andrew J Pollard

Affiliations

Soon will be listed here.

Abstract

In humans, the kinetics of the appearance of memory B cells and plasma cells during primary immunization are not well defined. In this study, we assessed the primary B-cell response of rabies-antigen naive volunteers during a 3-dose course of rabies vaccine compared with the B-cell response to a booster dose of rabies vaccine given to previously immunized volunteers. After a single dose of vaccine, in the naive group plasma and memory B cells appeared later (peak at day 10) than in the primed group (peak at day 7) and were at lower frequency. The most rapid responses (day 4) were detected after a third immunization in the naive group. This is the first study to document the detailed kinetics of the plasma cell and memory B-cell responses to immunization in adult humans and to demonstrate differences in the responses that relate to the preexisting immune status of the persons.

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