Identification of a Haplotype Block in the 5q31 Cytokine Gene Cluster Associated with the Susceptibility to Severe Malaria

Overview

Journal Malar J

Publisher Biomed Central

Specialty Tropical Medicine

Date 2009 Oct 21

PMID 19840389

Citations 12

Authors

Izumi Naka

Nao Nishida

Jintana Patarapotikul

Pornlada Nuchnoi

Katsushi Tokunaga

Hathairad Hananantachai

Naoyuki Tsuchiya

Jun Ohashi

Affiliations

Soon will be listed here.

Abstract

Background: It has been previously demonstrated that a single nucleotide polymorphism (SNP) in the IL13 promoter region, IL13 -1055T>C (rs1800925), was associated with susceptibility to severe malaria in Thais. In the present study, fine association mapping for a cytokine gene cluster including IL4, IL5, and IL13 on chromosome 5q31 was conducted using the same malaria subjects to refine the region containing a primary variant or a haplotype susceptible to severe malaria.

Methods: A total of 82 SNPs spanning 522 kb of the 5q31 region were analysed in 368 patients with Plasmodium falciparum malaria (203 mild malaria and 165 severe malaria patients).

Results: Only rs1881457 located in the promoter region of IL13, which is in linkage disequilibrium with rs1800925 (r2 = 0.73), showed a significant association with severe malaria after adjusting for multiple testing (P = 0.046 by permutation test). This SNP was in a haplotype block spanning 97 kb (from rs2069812 to rs2240032). The detected haplotype block contained the RAD50 gene and the promoter of IL13, but not the other genes.

Conclusion: A haplotype block in which a primary polymorphism associated with severe malaria is likely to be encoded was identified in Thai malaria patients.

Citing Articles

A fine mapping of single nucleotide variants and haplotype analysis of gene in patients with -cutaneous leishmaniasis and plasma cytokines IL-4, IL-5, and IL-13.

Junior J, de Souza J, da Silva L, da Silva C, do Nascimento T, de Souza M Front Immunol. 2023; 14:1232488.

PMID: 37908348 PMC: 10613733. DOI: 10.3389/fimmu.2023.1232488.

IL-4 gene polymorphisms and their association with nematodes infection in Pakistani population.

Afshan K, Sarfraz K, Kayani T, Firasat S Afr Health Sci. 2022; 22(2):216-228.

PMID: 36407356 PMC: 9652695. DOI: 10.4314/ahs.v22i2.25.

Pan-cancer chromatin analysis of the human vtRNA genes uncovers their association with cancer biology.

Fort R, Duhagon M F1000Res. 2021; 10:182.

PMID: 34354812 PMC: 8287541. DOI: 10.12688/f1000research.28510.2.

Host genetic polymorphisms and serological response against malaria in a selected population in Sri Lanka.

Dewasurendra R, Jeffreys A, Gunawardena S, Chandrasekharan N, Rockett K, Kwiatkowski D Malar J. 2018; 17(1):473.

PMID: 30558622 PMC: 6296029. DOI: 10.1186/s12936-018-2622-9.

Host genetics in malaria: lessons from mouse studies.

Huang H, McMorran B, Foote S, Burgio G Mamm Genome. 2018; 29(7-8):507-522.

PMID: 29594458 DOI: 10.1007/s00335-018-9744-9.

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