Vaccines for Venezuelan Equine Encephalitis

Overview

Journal Vaccine

Specialty Allergy & Immunology

Date 2009 Oct 20

PMID 19837294

Citations 54

Authors

Slobodan Paessler

Scott C Weaver

Affiliations

Soon will be listed here.

Abstract

Arboviruses are capable of causing encephalitis in animals and human population when transmitted by the vector or potentially via infectious aerosol. Recent re-emergence of Venezuelan equine encephalitis virus (VEEV) in South America emphasizes the importance of this pathogen to public health and veterinary medicine. Despite its importance no antivirals or vaccines against VEEV are currently available in the USA. Here we review some of the older and newer approaches aimed at generating a safe and immunogenic vaccine as well as most recent data about the mechanistic of protection in animal models of infection.

Citing Articles

Replication of the Venezuelan Equine Encephalitis Vaccine from a Synthetic PCR Fragment.

Mathew C, Tucker C, Tretyakova I, Pushko P Pharmaceutics. 2024; 16(9).

PMID: 39339253 PMC: 11434715. DOI: 10.3390/pharmaceutics16091217.

Single-Dose Immunogenic DNA Vaccines Coding for Live-Attenuated Alpha- and Flaviviruses.

Pushko P, Lukashevich I, Johnson D, Tretyakova I Viruses. 2024; 16(3).

PMID: 38543793 PMC: 10974764. DOI: 10.3390/v16030428.

MVA-based vaccines are protective against lethal eastern equine encephalitis virus aerosol challenge in cynomolgus macaques.

Beddingfield B, Plante K, Plante J, Weaver S, Bose S, Krzykwa C NPJ Vaccines. 2024; 9(1):47.

PMID: 38413593 PMC: 10899228. DOI: 10.1038/s41541-024-00842-y.

Live-Attenuated VEEV Vaccine Delivered by iDNA Using Microneedles Is Immunogenic in Rabbits.

Tretyakova I, Tomai M, Vasilakos J, Pushko P Front Trop Dis. 2023; 3.

PMID: 37854093 PMC: 10583749. DOI: 10.3389/fitd.2022.813671.

Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice.

Kafai N, Janova H, Cain M, Alippe Y, Muraro S, Sariol A Cell Rep. 2023; 42(8):112946.

PMID: 37556325 PMC: 10529316. DOI: 10.1016/j.celrep.2023.112946.

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