Genome Wide DNA-profiling of HIV-related B-cell Lymphomas

Overview

Journal Br J Haematol

Specialty Hematology

Date 2009 Oct 17

PMID 19832807

Citations 36

Authors

Daniela Capello

Marta Scandurra

Giulia Poretti

Paola M V Rancoita

Michael Mian

Annunziata Gloghini

Clara Deambrogi

Maurizio Martini

Davide Rossi

Timothy C Greiner

Wing C Chan

Maurilio Ponzoni

Santiago M Moreno

Miguel A Piris

Vincenzo Canzonieri

Michele Spina

Umberto Tirelli

Giorgio Inghirami

Andrea Rinaldi

Emanuele Zucca

Riccardo D Favera

Franco Cavalli

Luigi Maria Larocca

Ivo Kwee

Antonino Carbone

Gianluca Gaidano

Francesco Bertoni

Affiliations

Soon will be listed here.

Abstract

Non-Hodgkin lymphomas (NHL) represent a frequent complication of human immunodeficiency virus (HIV) infection. To elucidate HIV-NHL pathogenesis, we performed a genome-wide DNA profiling based on a single nucleotide polymorphism-based microarray comparative genomic hybridization in 57 HIV-lymphomas and, for comparison, in 105 immunocompetent diffuse large B-cell lymphomas (IC-DLBCL). Genomic complexity varied across HIV-NHL subtypes. HIV-Burkitt lymphoma showed a significantly lower number of lesions than HIV-DLBCL (P = 0.032), whereas the median number of copy number changes was significantly higher in Epstein-Barr virus negative (EBV-) HIV-DLBCL (42.5, range 8-153) compared to EBV+ cases (22; range 3-41; P = 0.029). Compared to IC-DLBCL, HIV-DLBCL displayed a distinct genomic profile with no gains of 18q and specific genetic lesions. Fragile sites-associated genes, including FHIT (FRA3B), WWOX (FRA16D), DCC (FRA18B) and PARK2 (FRA6E) were frequently inactivated in HIV-NHL by interstitial deletions, and a significantly higher prevalence of FHIT alterations was observed in HIV-DLBCL compared to IC-DLBCL. The same genes involved by fragile site deletions were also frequently affected by aberrant methylation of regulative regions.

Citing Articles

Immune Characteristics and Immunotherapy of HIV-Associated Lymphoma.

Liu Y, Xie X, Li J, Xiao Q, He S, Fu H Curr Issues Mol Biol. 2024; 46(9):9984-9997.

PMID: 39329948 PMC: 11429793. DOI: 10.3390/cimb46090596.

HIV infection and ART exposure affect tumor TCR repertoire of diffuse large B cell lymphoma.

Roush S, Coelho J, Xu A, Puranam K, Mponda M, Kasonkanji E JCI Insight. 2024; 9(13).

PMID: 38781015 PMC: 11383373. DOI: 10.1172/jci.insight.180771.

HIV and prior exposure to antiretroviral therapy alter tumour composition and tumour: T-cell associations in diffuse large B-cell lymphoma.

Coelho J, Roush S, Xu A, Puranam K, Mponda M, Kasonkanji E Br J Haematol. 2024; 205(1):194-206.

PMID: 38769021 PMC: 11245366. DOI: 10.1111/bjh.19531.

Still Far to Go With Characterisation of Molecular and Genetic Features of Diffuse Large B-Cell Lymphoma in People Living With HIV: A Scoping Review.

Manyau M, Zambuko B, Chatambudza M, Zhou D, Manasa J Oncol Rev. 2024; 18:1375291.

PMID: 38707485 PMC: 11066230. DOI: 10.3389/or.2024.1375291.

Carcinogenic mechanisms of virus-associated lymphoma.

Zhang Y, Guo W, Zhan Z, Bai O Front Immunol. 2024; 15:1361009.

PMID: 38482011 PMC: 10932979. DOI: 10.3389/fimmu.2024.1361009.

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