The Linkage of Chromatin Remodeling to Genome Maintenance: Contribution from a Human Disease Gene BRIT1/MCPH1

Overview

Journal Epigenetics

Specialty Genetics

Date 2009 Oct 16

PMID 19829069

Citations 4

Authors

Guang Peng

Shiaw-Yih Lin

Affiliations

Soon will be listed here.

Abstract

Genomic DNA is packed into a highly condensed chromatin structure, which acts as natural barrier preventing accessibility of DNA. In various processes to maintain genomic integrity such as DNA replication, DNA repair, telomere regulation, proteins need to overcome the barrier of condensed chromatin to gain access to DNA. ATP-dependent chromatin remodeling is one of the fundamental mechanisms used by cells to relax chromatin. However, the chromatin remodeling complex does not contain intrinsic specificity for particular nuclear process, and the mechanism mediating its recruitment to DNA lesions remains to be an outstanding question. To address this question, in this review, we will discuss our current findings and future perspectives about how BRIT1/MCPH1, a human disease gene, specifies the function of chromatin remodelers and links chromatin remodeling to genome maintenance.

Citing Articles

MCPH1 is essential for cellular adaptation to the G-phase decatenation checkpoint.

Arroyo M, Kuriyama R, Guerrero I, Keifenheim D, Canuelo A, Calahorra J FASEB J. 2019; 33(7):8363-8374.

PMID: 30964711 PMC: 6593890. DOI: 10.1096/fj.201802009RR.

BRCT-domain protein BRIT1 influences class switch recombination.

Yen W, Chaudhry A, Vaidyanathan B, Yewdell W, Pucella J, Sharma R Proc Natl Acad Sci U S A. 2017; 114(31):8354-8359.

PMID: 28724724 PMC: 5547652. DOI: 10.1073/pnas.1708211114.

Telomere shortening and Alzheimer's disease.

Cai Z, Yan L, Ratka A Neuromolecular Med. 2012; 15(1):25-48.

PMID: 23161153 DOI: 10.1007/s12017-012-8207-9.

Exploiting the homologous recombination DNA repair network for targeted cancer therapy.

Peng G, Lin S World J Clin Oncol. 2011; 2(2):73-9.

PMID: 21603316 PMC: 3095467. DOI: 10.5306/wjco.v2.i2.73.

References

Morrison A, Highland J, Krogan N, Arbel-Eden A, Greenblatt J, Haber J . INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair. Cell. 2004; 119(6):767-75. DOI: 10.1016/j.cell.2004.11.037. View

dAdda di Fagagna F, Teo S, Jackson S . Functional links between telomeres and proteins of the DNA-damage response. Genes Dev. 2004; 18(15):1781-99. DOI: 10.1101/gad.1214504. View

Huang C, Sloan E, Boerkoel C . Chromatin remodeling and human disease. Curr Opin Genet Dev. 2003; 13(3):246-52. DOI: 10.1016/s0959-437x(03)00054-6. View

de Lange T . Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 2005; 19(18):2100-10. DOI: 10.1101/gad.1346005. View

Park J, Park E, Lee H, Kim S, Hur S, Imbalzano A . Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction. EMBO J. 2006; 25(17):3986-97. PMC: 1560357. DOI: 10.1038/sj.emboj.7601291. View

Peterson C, Workman J . Promoter targeting and chromatin remodeling by the SWI/SNF complex. Curr Opin Genet Dev. 2000; 10(2):187-92. DOI: 10.1016/s0959-437x(00)00068-x. View

Morrison A, Kim J, Person M, Highland J, Xiao J, Wehr T . Mec1/Tel1 phosphorylation of the INO80 chromatin remodeling complex influences DNA damage checkpoint responses. Cell. 2007; 130(3):499-511. DOI: 10.1016/j.cell.2007.06.010. View

Kouzarides T . Chromatin modifications and their function. Cell. 2007; 128(4):693-705. DOI: 10.1016/j.cell.2007.02.005. View

Narlikar G, Fan H, Kingston R . Cooperation between complexes that regulate chromatin structure and transcription. Cell. 2002; 108(4):475-87. DOI: 10.1016/s0092-8674(02)00654-2. View

10.

Yu X, Chini C, He M, Mer G, Chen J . The BRCT domain is a phospho-protein binding domain. Science. 2003; 302(5645):639-42. DOI: 10.1126/science.1088753. View

11.

Flanagan J, Mi L, Chruszcz M, Cymborowski M, Clines K, Kim Y . Double chromodomains cooperate to recognize the methylated histone H3 tail. Nature. 2005; 438(7071):1181-5. DOI: 10.1038/nature04290. View

12.

Matsuoka S, Ballif B, Smogorzewska A, McDonald 3rd E, Hurov K, Luo J . ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007; 316(5828):1160-6. DOI: 10.1126/science.1140321. View

13.

Wu X, Mondal G, Wang X, Wu J, Yang L, Pankratz V . Microcephalin regulates BRCA2 and Rad51-associated DNA double-strand break repair. Cancer Res. 2009; 69(13):5531-6. PMC: 2706938. DOI: 10.1158/0008-5472.CAN-08-4834. View

14.

ODriscoll M, Jackson A, Jeggo P . Microcephalin: a causal link between impaired damage response signalling and microcephaly. Cell Cycle. 2006; 5(20):2339-44. DOI: 10.4161/cc.5.20.3358. View

15.

Huen M, Chen J . The DNA damage response pathways: at the crossroad of protein modifications. Cell Res. 2007; 18(1):8-16. DOI: 10.1038/cr.2007.109. View

16.

Rai R, Dai H, Multani A, Li K, Chin K, Gray J . BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell. 2006; 10(2):145-57. PMC: 1557410. DOI: 10.1016/j.ccr.2006.07.002. View

17.

Jeffers L, Coull B, Stack S, Morrison C . Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization. Oncogene. 2007; 27(1):139-44. DOI: 10.1038/sj.onc.1210595. View

18.

Chaplet M, Rai R, Jackson-Bernitsas D, Li K, Lin S . BRIT1/MCPH1: a guardian of genome and an enemy of tumors. Cell Cycle. 2006; 5(22):2579-83. DOI: 10.4161/cc.5.22.3471. View

19.

Tibelius A, Marhold J, Zentgraf H, Heilig C, Neitzel H, Ducommun B . Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1. J Cell Biol. 2009; 185(7):1149-57. PMC: 2712957. DOI: 10.1083/jcb.200810159. View

20.

Bergink S, Jentsch S . Principles of ubiquitin and SUMO modifications in DNA repair. Nature. 2009; 458(7237):461-7. DOI: 10.1038/nature07963. View