Inhibition of CAMP Responsive Element Binding Protein in Striatal Neurons Enhances Approach and Avoidance Responses Toward Morphine--and Morphine Withdrawal-related Cues

Overview

Journal Front Behav Neurosci

Specialty Psychology

Date 2009 Oct 15

PMID 19826619

Citations 6

Authors

Carles Sanchis-Segura

Dragana Jancic

Maria Jimenez-Minchan

Angel Barco

Affiliations

Soon will be listed here.

Abstract

To investigate the role of cAMP responsive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB family of transcription factors, A-CREB, in striatal neurons in a regulatable manner. The expression of A-CREB in the striatum enhanced both morphine-induced conditioned place preference and morphine withdrawal-induced conditioned place avoidance. Our experiments thereby support a role for CREB in striatal neurons regulating approach and avoidance responses toward drug-related cues.

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