Aging Epidermis is Maintained by Changes in Transit-amplifying Cell Kinetics, Not Stem Cell Kinetics

Overview

Journal J Invest Dermatol

Publisher Elsevier

Specialty Dermatology

Date 2009 Oct 15

PMID 19826444

Citations 5

Authors

Michael C Winter

Jackie R Bickenbach

Affiliations

Soon will be listed here.

Abstract

It has been assumed that the slow rate of healing in aging epidermis is due to slowing of the epidermal stem cell proliferative rate. In this issue, Charruyer et al. report that this may not be the case. Using a long-term repopulating model, they demonstrate that epidermal stem cell kinetics are maintained. Instead, it is the compensatory action of the transit-amplifying (TA) cells that changes in aging skin and thus bears responsibility for slowed wound healing.

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CD133 is a marker for long-term repopulating murine epidermal stem cells.

Charruyer A, Strachan L, Yue L, Toth A, Cecchini G, Mancianti M J Invest Dermatol. 2012; 132(11):2522-33.

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Velarde M, Flynn J, Day N, Melov S, Campisi J Aging (Albany NY). 2012; 4(1):3-12.

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