Familial Association of Pancreatic Cancer with Other Malignancies in Swedish Families

Overview

Journal Br J Cancer

Specialty Oncology

Date 2009 Oct 15

PMID 19826425

Citations 16

Authors

E Hiripi

J Lorenzo Bermejo

X Li

J Sundquist

K Hemminki

Affiliations

Soon will be listed here.

Abstract

Background: The aim of this study was to characterise the familial association of pancreatic cancer with other malignancies.

Methods: Relative risks (RRs) of pancreatic cancer according to family history of cancer were calculated using the updated Swedish Family-Cancer Database, which includes over 11.5 million individuals. Estimates were based on Poisson regression. RRs of tumours for individuals with a parental history of pancreatic cancer were also estimated.

Results: The risk of pancreatic cancer was elevated in individuals with a parental history of cancers of the liver (RR 1.41; 95% CI 1.10-1.81), kidney (RR 1.37; 95% CI 1.06-1.76), lung (RR 1.50; 95% CI 1.27-1.79) and larynx (RR 1.98; 95% CI 1.19-3.28). Associations were also found between parental history of pancreatic cancer and cancers of the small intestine, colon, breast, lung, testis and cervix in offspring. There was an increased risk of pancreatic cancer associated with early-onset breast cancer in siblings.

Conclusion: Pancreatic cancer aggregates in families with several types of cancer. Smoking may contribute to the familial aggregation of pancreatic and lung tumours, and the familial clustering of pancreatic and breast cancer could be partially explained by inherited mutations in the BRCA2 gene.

Citing Articles

Investigating the tissue specificity and prognostic impact of cis-regulatory cancer risk variants.

Subramanian A, Su S, Moding E, Binkley M Hum Genet. 2023; 142(9):1395-1405.

PMID: 37474751 DOI: 10.1007/s00439-023-02586-6.

Genetics, Genomics and Emerging Molecular Therapies of Pancreatic Cancer.

Liu J, Mroczek M, Mach A, Stepien M, Aplas A, Pronobis-Szczylik B Cancers (Basel). 2023; 15(3).

PMID: 36765737 PMC: 9913594. DOI: 10.3390/cancers15030779.

Intraductal Papillary Mucinous Neoplasms in Hereditary Cancer Syndromes.

Ardeshna D, Rangwani S, Cao T, Pawlik T, Stanich P, Krishna S Biomedicines. 2022; 10(7).

PMID: 35884779 PMC: 9313108. DOI: 10.3390/biomedicines10071475.

Pancreatic cancer risk to siblings of probands in bilineal cancer settings.

Rabe K, Stevens M, Hernandez A, Chandra S, Hubbard J, Kemppainen J Genet Med. 2022; 24(5):1008-1016.

PMID: 35227607 PMC: 9326771. DOI: 10.1016/j.gim.2022.01.016.

Molecular Features and Clinical Management of Hereditary Pancreatic Cancer Syndromes and Familial Pancreatic Cancer.

Kasuga A, Okamoto T, Udagawa S, Mori C, Mie T, Furukawa T Int J Mol Sci. 2022; 23(3).

PMID: 35163129 PMC: 8835700. DOI: 10.3390/ijms23031205.

References

Hemminki K, Li X, Plna K, Granstrom C, Vaittinen P . The nation-wide Swedish family-cancer database--updated structure and familial rates. Acta Oncol. 2002; 40(6):772-7. DOI: 10.1080/02841860152619214. View

Raimondi S, Maisonneuve P, Lohr J, Lowenfels A . Early onset pancreatic cancer: evidence of a major role for smoking and genetic factors. Cancer Epidemiol Biomarkers Prev. 2007; 16(9):1894-7. DOI: 10.1158/1055-9965.EPI-07-0341. View

Klein A, Hruban R, Brune K, Petersen G, Goggins M . Familial pancreatic cancer. Cancer J. 2001; 7(4):266-73. View

Jaffee E, Hruban R, Canto M, Kern S . Focus on pancreas cancer. Cancer Cell. 2002; 2(1):25-8. DOI: 10.1016/s1535-6108(02)00093-4. View

Gayther S, Ponder B . Mutations of the BRCA1 and BRCA2 genes and the possibilities for predictive testing. Mol Med Today. 1997; 3(4):168-74. DOI: 10.1016/S1357-4310(97)01017-4. View

Howes N, Lerch M, Greenhalf W, Stocken D, Ellis I, Simon P . Clinical and genetic characteristics of hereditary pancreatitis in Europe. Clin Gastroenterol Hepatol. 2004; 2(3):252-61. DOI: 10.1016/s1542-3565(04)00013-8. View

Lorenzo Bermejo J, Hemminki K . Familial association of histology specific breast cancers with cancers at other sites. Int J Cancer. 2004; 109(3):430-5. DOI: 10.1002/ijc.11713. View

Couch F, Johnson M, Rabe K, Brune K, de Andrade M, Goggins M . The prevalence of BRCA2 mutations in familial pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2007; 16(2):342-6. DOI: 10.1158/1055-9965.EPI-06-0783. View

MacLeod S, Chowdhury P . The genetics of nicotine dependence: relationship to pancreatic cancer. World J Gastroenterol. 2006; 12(46):7433-9. PMC: 4087587. DOI: 10.3748/wjg.v12.i46.7433. View

10.

Agalliu I, Karlins E, Kwon E, Iwasaki L, Diamond A, Ostrander E . Rare germline mutations in the BRCA2 gene are associated with early-onset prostate cancer. Br J Cancer. 2007; 97(6):826-31. PMC: 2360390. DOI: 10.1038/sj.bjc.6603929. View

11.

Rebours V, Boutron-Ruault M, Schnee M, Ferec C, Le Marechal C, Hentic O . The natural history of hereditary pancreatitis: a national series. Gut. 2008; 58(1):97-103. DOI: 10.1136/gut.2008.149179. View

12.

McWilliams R, Rabe K, Olswold C, de Andrade M, Petersen G . Risk of malignancy in first-degree relatives of patients with pancreatic carcinoma. Cancer. 2005; 104(2):388-94. DOI: 10.1002/cncr.21166. View

13.

Lynch H, de la Chapelle A . Hereditary colorectal cancer. N Engl J Med. 2003; 348(10):919-32. DOI: 10.1056/NEJMra012242. View

14.

Fitzgerald M, MacDonald D, Krainer M, Hoover I, ONeil E, Unsal H . Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer. N Engl J Med. 1996; 334(3):143-9. DOI: 10.1056/NEJM199601183340302. View

15.

Greer J, Whitcomb D, Brand R . Genetic predisposition to pancreatic cancer: a brief review. Am J Gastroenterol. 2007; 102(11):2564-9. DOI: 10.1111/j.1572-0241.2007.01475.x. View

16.

Hemminki K, Vaittinen P, Kyyronen P . Age-specific familial risks in common cancers of the offspring. Int J Cancer. 1998; 78(2):172-5. DOI: 10.1002/(sici)1097-0215(19981005)78:2<172::aid-ijc9>3.0.co;2-w. View

17.

Hemminki K, Li X, Sundquist K, Sundquist J . Shared familial aggregation of susceptibility to autoimmune diseases. Arthritis Rheum. 2009; 60(9):2845-7. DOI: 10.1002/art.24749. View

18.

Lerch M . Anticipating disaster: the genetics of familial pancreatic cancer. Gut. 2006; 55(2):150-1. PMC: 1856499. DOI: 10.1136/gut.2005.075101. View

19.

Greenhalf W, Neoptolemos J . Increasing survival rates of patients with pancreatic cancer by earlier identification. Nat Clin Pract Oncol. 2006; 3(7):346-7. DOI: 10.1038/ncponc0483. View

20.

Hemminki K, Vaittinen P . Familial cancers in a nationwide family cancer database: age distribution and prevalence. Eur J Cancer. 1999; 35(7):1109-17. DOI: 10.1016/s0959-8049(99)00066-0. View