Age-associated Increase in Lifespan of Naive CD4 T Cells Contributes to T-cell Homeostasis but Facilitates Development of Functional Defects

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2009 Oct 10

PMID 19815516

Citations 86

Authors

Hirotake Tsukamoto

Karen Clise-Dwyer

Gail E Huston

Debra K Duso

Amanda L Buck

Lawrence L Johnson

Laura Haynes

Susan L Swain

Affiliations

Soon will be listed here.

Abstract

With age, T-cell generation from the thymus is much reduced, yet a substantial naïve T-cell pool is maintained even in aged animals, suggesting that naïve T cells either persist longer or turn over faster to maintain T-cell homeostasis. We found that with age, naïve CD4 T cells became progressively longer-lived. Their longer lifespan did not depend on recognition of self-peptide/class II. Newly generated naïve T cells derived from aged stem cells had a shorter lifespan, like that of young naïve T cells. Conversely, naïve CD4 T cells derived from middle-aged thymectomized mice were longer-lived in vivo, and their development of functional defects was accelerated. These observations suggest that naïve T cells develop their longer lifespan during their sojourn in the periphery. Increased longevity of naïve CD4 T cells correlated well with reduced expression of proapoptotic molecule Bim. We suggest that the intrinsic increase in longevity helps maintain naïve T-cell homeostasis but facilitates the development of functional defects in mice.

Citing Articles

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