Impact of CPAP Treatment on Cardiac Biomarkers and Pro-BNP in Obstructive Sleep Apnea Syndrome

Overview

Journal Sleep Breath

Publisher Springer

Date 2009 Oct 9

PMID 19813037

Citations 29

Authors

Nilufer Cifci

Meral Uyar

Osman Elbek

Huseyin Suyur

Erhan Ekinci

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the effect of continuous positive airway pressure (CPAP) therapy on pro-brain natriuretic peptide (BNP) and cardiac markers in patients with obstructive sleep apnea syndrome and normal cardiac function.

Methods: Thirty-three consecutive patients with sleep apnea syndrome were analysed for serum pro-BNP and cardiac markers prior to and after 6 months of CPAP therapy.

Results: Twenty five patients had normal (83.3%) while remaining five (16.7%) revealed high pro-BNP values. We did not detect any significant difference between severity of obstructive sleep apnea syndrome and serum pro-BNP levels (p = 0.534). A statistically significant difference was not observed between basal and sixth-month creatine kinase (CK), creatine kinase-MB (CK-MB), troponin I, pro-BNP, aspartate transaminase (AST), and CK levels in patients with sleep apnea syndrome (p > 0.05).

Conclusion: Obstructive sleep apnea syndrome does not induce myocardial damage enough to increase serum pro-BNP, CK, CK-MB, troponin I, and AST levels. Markers sensitive to ischemia could be preferred to evaluate effect of obstructive sleep apnea syndrome.

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