Autoimmune Cytopenia in Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma: Changes in Clinical Presentation and Prognosis

Overview

Journal Leuk Lymphoma

Specialties Hematology
Oncology

Date 2009 Oct 9

PMID 19811329

Citations 23

Authors

Clive S Zent

Wei Ding

Megan S Reinalda

Susan M Schwager

James D Hoyer

Deborah A Bowen

Diane F Jelinek

Renee C Tschumper

Timothy G Call

Tait D Shanafelt

Neil E Kay

Susan L Slager

Affiliations

Soon will be listed here.

Abstract

Improved medical care could have altered the clinical presentation and survival of patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) complicated by autoimmune disease cytopenia (AID cytopenia). We reviewed the clinical characteristics, treatment, and outcome of AID cytopenia that was diagnosed in 75 (4.3%) of 1750 patients with CLL seen at a single institution over 10 years. When compared with the historical reported data, our study shows a lower rate of autoimmune hemolytic anemia (2.3%), and similar rates of immune thrombocytopenia (2.0%), and pure red blood cell aplasia (0.5%). AID cytopenia occurred at all stages of CLL, responded well to treatment, did not alter overall survival, and contributed to death in only 6 (12%) patients. We propose that more sensitive and accurate diagnostic methods for CLL have decreased the perceived prevalence of AID cytopenia and that improvements in management could have increased the survival of these patients.

Citing Articles

A Peculiar CLL Case with Complex Chromosome 6 Rearrangements and Refinement of All Breakpoints at the Gene Level by Genomic Array: A Case Report.

Cennamo M, Sirocchi D, Giudici C, Giagnacovo M, Petracco G, Ferrario D J Clin Med. 2023; 12(12).

PMID: 37373803 PMC: 10299087. DOI: 10.3390/jcm12124110.

Older Adults and Immune Thrombocytopenia: Considerations for the Clinician.

Crickx E, Mahevas M, Michel M, Godeau B Clin Interv Aging. 2023; 18:115-130.

PMID: 36726813 PMC: 9885884. DOI: 10.2147/CIA.S369574.

Treatment of chemotherapy-induced thrombocytopenia in patients with non-hematologic malignancies.

Kuter D Haematologica. 2022; 107(6):1243-1263.

PMID: 35642485 PMC: 9152964. DOI: 10.3324/haematol.2021.279512.

Autoimmune Hemolytic Anemia in Chronic Lymphocytic Leukemia: A Comprehensive Review.

Autore F, Pasquale R, Innocenti I, Fresa A, Sora F, Laurenti L Cancers (Basel). 2021; 13(22).

PMID: 34830959 PMC: 8616265. DOI: 10.3390/cancers13225804.

How I manage autoimmune cytopenias in patients with lymphoid cancer.

Porpaczy E, Jager U Blood. 2021; 139(10):1479-1488.

PMID: 34517415 PMC: 11017954. DOI: 10.1182/blood.2019003686.

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