Characterization of the Local and Systemic Virus Neutralizing Activity in Swine Vaccinated with a Porcine Enterovirus

Overview

Journal Can J Comp Med

Specialty Veterinary Medicine

Date 1977 Jul 1

PMID 198074

Citations 3

Authors

D T Hazlett

J B Derbyshire

Affiliations

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Abstract

The virus neutralizing substance in the gastrointestinal tract of swine vaccinated in different ways with porcine enterovirus strain T80 was characterized by tests for enhancement and absorption of virus neutralizing activity by class specific antiporcine Ig antisera. The gastrointestinal virus neutralizing activity of piglets which were vaccinated with live virus orally resided predominantly in the IgA class, although some activity was present also in the IgM and IgG classes. The serum virus neutralizing activity of this group was present in all three classes but primarily in the IgG class. The IgA in the serum of this group was presumably of gut origin. However, in piglets vaccinated with live virus intramuscularly, with formaldehyde-inactivated virus orally or intramuscularly or with ethylenimine-inactivated virus by both oral and subcutaneous routes, both serum and gastrointestinal virus neutralizing activity were attributable predominantly to antibodies of the IgG and IgM classes. None possessed serum IgA. There was evidence also for the presence of Ig fragments in some gastrointestinal extracts.

Citing Articles

The effect of immunosuppression with cyclophosphamide on an experimental porcine enterovirus infection in piglets.

Derbyshire J Can J Comp Med. 1983; 47(2):235-7.

PMID: 6224548 PMC: 1235923.

Cell mediated responses in a porcine enterovirus infection in piglets.

Brundage L, Derbyshire J, Wilkie B Can J Comp Med. 1980; 44(1):61-9.

PMID: 6156747 PMC: 1320035.

The protective effect of two porcine enterovirus vaccines in swine.

Hazlett D, Derbyshire J Can J Comp Med. 1977; 41(3):264-73.

PMID: 198075 PMC: 1277589.

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