Current Status of Xenotransplantation and Prospects for Clinical Application

Overview

Journal Xenotransplantation

Specialty General Surgery

Date 2009 Oct 3

PMID 19796067

Citations 50

Authors

Richard N Pierson 3rd

Anthony Dorling

David Ayares

Michael A Rees

Jorg D Seebach

Jay A Fishman

Bernhard J Hering

David K C Cooper

Affiliations

Soon will be listed here.

Abstract

Xenotransplantation is one promising approach to bridge the gap between available human cells, tissues, and organs and the needs of patients with diabetes or end-stage organ failure. Based on recent progress using genetically modified source pigs, improving results with conventional and experimental immunosuppression, and expanded understanding of residual physiologic hurdles, xenotransplantation appears likely to be evaluated in clinical trials in the near future for some select applications. This review offers a comprehensive overview of known mechanisms of xenograft injury, a contemporary assessment of preclinical progress and residual barriers, and our opinions regarding where breakthroughs are likely to occur.

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