Correlations Between Natural Resistance to Doxorubicin, Proliferative Activity, and Expression of P-glycoprotein 170 in Human Kidney Tumor Cell Lines

Overview

Journal Urol Res

Specialty Urology

Date 1990 Jan 1

PMID 1979457

Citations 3

Authors

T Efferth

H Lohrke

M Volm

Affiliations

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Abstract

The natural resistance to doxorubicin of 15 human renal carcinoma cell lines was analyzed and compared to proliferative activity and expression of P-glycoprotein. We found a significant negative correlation between proliferative activity and natural resistance to doxorubicin, as well as between proliferative activity and the expression of P-glycoprotein. A positive correlation between resistance and expression of P-glycoprotein was found.

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