The Ubiquitin-proteasome System in Myocardial Ischaemia and Preconditioning

Overview

Journal Cardiovasc Res

Specialty Cardiology & Vascular Diseases

Date 2009 Oct 2

PMID 19793765

Citations 21

Authors

Saul R Powell

Andras Divald

Affiliations

Soon will be listed here.

Abstract

The ubiquitin-proteasome system (UPS) represents the major pathway for degradation of intracellular proteins. This article reviews the major components and configurations of the UPS including the 26S proteasome and 11S activated proteasome relevant to myocardial ischaemia. We then present the evidence that the UPS is dysfunctional during myocardial ischaemia as well as potential consequences of this, including dysregulation of target substrates, many of them active signalling proteins, and accumulation of oxidized proteins. As part of this discussion, potential mechanisms, including ATP depletion, inhibition by insoluble protein aggregates, and oxidation of proteasome and regulatory particle subunits, are discussed. Finally, the evidence suggesting a role for the UPS in ischaemic preconditioning is presented. Much of this is inferential but clearly indicates the need for additional research.

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