Spontaneous Pathology of the Baboon Endocrine System

Overview

Journal J Med Primatol

Publisher Wiley

Date 2009 Oct 2

PMID 19793179

Citations 13

Authors

R Guardado-Mendoza

E J Dick Jr

L M Jimenez-Ceja

A Davalli

A O Chavez

F Folli

G B Hubbard

Affiliations

Soon will be listed here.

Abstract

Background: Study of endocrine pathology in animal models is critical to understanding endocrine pathology in humans.

Methods: We evaluated 434 endocrine-related diagnoses from 4619 baboon necropsies, established the incidence of spontaneous endocrine pathology, and analyzed the clinical and biochemical data associated with the individual cases.

Results: The most common diagnoses in descending order, were pancreatic islet cell amyloidosis (n = 259), ovarian cysts (n = 50), pituitary adenoma (n = 37), pancreatic islet cell adenoma (n = 20), granulosa cell tumor (n = 15), thyroid adenoma (n = 11), adrenal hyperplasia (n = 10), thyroid carcinoma (n = 8), and pheochromocytoma (n = 6). The incidence of pancreatic islet cell amyloidosis progressively increased with age. Pheochromocytomas were associated with renal and heart failure. The incidence of pancreatic islet cell amyloidosis and adrenal pathology was similar to humans; the incidence of pituitary adenoma and thyroid pathology was lower than in humans.

Conclusions: Endocrine disease in baboons is common and shares clinical and biochemical characteristics with endocrine disease in humans.

Citing Articles

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Plesker R, Kohler K Primate Biol. 2024; 10(1):1-6.

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Bakker J, de la Garza M Animals (Basel). 2022; 12(4).

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Research Relevant Conditions and Pathology in Nonhuman Primates.

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Plesker R, Hintereder G Primate Biol. 2021; 8(1):37-42.

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Multiple endocrine neoplasia-like syndrome in 24 baboons (Papio spp.).

Confer A, Owston M, Kumar S, Dick Jr E J Med Primatol. 2018; 47(6):434-439.

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