The Efficacy of Monepantel, an Amino-acetonitrile Derivative, Against Gastrointestinal Nematodes of Sheep in Three Countries of Southern Latin America

Overview

Journal Parasitol Res

Specialty Parasitology

Date 2009 Oct 1

PMID 19789895

Citations 5

Authors

Miguel Bustamante

Pedro E Steffan

Jorge Bonino Morlan

Flavio Echevarria

Cesar A Fiel

Herculano Cardozo

Daniel Castells

Barry C Hosking

Affiliations

Soon will be listed here.

Abstract

The efficacy of the novel anthelmintic, monepantel (an amino-acetonitrile derivative), was investigated in sheep naturally infected with gastrointestinal nematodes in five studies in Argentina, Brazil, and Uruguay. Monepantel, administered at 2.5 mg/kg liveweight, was highly effective (>99.7%) against Haemonchus contortus, Teladorsagia (Ostertagia) circumcincta, Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia curticei, Cooperia mcmasteri, Cooperia oncophora, Cooperia pectinata, Cooperia punctata, and Nematodirus spathiger, including strains resistant to the older broad-spectrum anthelmintics. Efficacy against C. mcmasteri, C. pectinata, and C. punctata is documented for the first time. The treatment with monepantel was well tolerated by the sheep.

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References

Nari A, Salles J, Gil A, Waller P, Hansen J . The prevalence of anthelmintic resistance in nematode parasites of sheep in southern Latin America: Uruguay. Vet Parasitol. 1996; 62(3-4):213-22. DOI: 10.1016/0304-4017(95)00908-6. View

Vercruysse J, Holdsworth P, Letonja T, Barth D, Conder G, Hamamoto K . International harmonisation of anthelmintic efficacy guidelines. Vet Parasitol. 2001; 96(3):171-93. DOI: 10.1016/s0304-4017(00)00443-x. View

Hosking B, Stein P, Mosimann D, Seewald W, Strehlau G, Kaminsky R . Dose determination studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep. Vet Parasitol. 2008; 157(1-2):72-80. DOI: 10.1016/j.vetpar.2008.07.014. View

Kaminsky R, Ducray P, Jung M, Clover R, Rufener L, Bouvier J . A new class of anthelmintics effective against drug-resistant nematodes. Nature. 2008; 452(7184):176-80. DOI: 10.1038/nature06722. View

Maciel S, GIMENEZ A, Gaona C, Waller P, Hansen J . The prevalence of anthelmintic resistance in nematode parasites of sheep in southern Latin America: Paraguay. Vet Parasitol. 1996; 62(3-4):207-12. DOI: 10.1016/0304-4017(95)00907-8. View

Wood I, Amaral N, Bairden K, Duncan J, Kassai T, Malone Jr J . World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) second edition of guidelines for evaluating the efficacy of anthelmintics in ruminants (bovine, ovine, caprine). Vet Parasitol. 1995; 58(3):181-213. DOI: 10.1016/0304-4017(95)00806-2. View

Kaminsky R, Gauvry N, Schorderet Weber S, Skripsky T, Bouvier J, Wenger A . Identification of the amino-acetonitrile derivative monepantel (AAD 1566) as a new anthelmintic drug development candidate. Parasitol Res. 2008; 103(4):931-9. PMC: 2491438. DOI: 10.1007/s00436-008-1080-7. View

POWERS K, Wood I, Eckert J, Gibson T, Smith H . World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guidelines for evaluating the efficacy of anthelmintics in ruminants (bovine and ovine). Vet Parasitol. 1982; 10(4):265-84. DOI: 10.1016/0304-4017(82)90078-4. View

Sager H, Hosking B, Bapst B, Stein P, Vanhoff K, Kaminsky R . Efficacy of the amino-acetonitrile derivative, monepantel, against experimental and natural adult stage gastro-intestinal nematode infections in sheep. Vet Parasitol. 2008; 159(1):49-54. DOI: 10.1016/j.vetpar.2008.10.006. View

10.

Hosking B, Dobson D, Stein P, Kaminsky R, Bapst B, Mosimann D . Dose confirmation studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep. Vet Parasitol. 2009; 160(3-4):251-7. DOI: 10.1016/j.vetpar.2008.11.028. View

11.

Echevarria F, Borba M, Pinheiro A, Waller P, Hansen J . The prevalence of anthelmintic resistance in nematode parasites of sheep in southern Latin America: Brazil. Vet Parasitol. 1996; 62(3-4):199-206. DOI: 10.1016/0304-4017(95)00906-x. View

12.

Eddi C, Caracostantogolo J, Pena M, Schapiro J, Marangunich L, Waller P . The prevalence of anthelmintic resistance in nematode parasites of sheep in southern Latin America: Argentina. Vet Parasitol. 1996; 62(3-4):189-97. DOI: 10.1016/0304-4017(95)00905-1. View

13.

Kaminsky R, Mosimann D, Sager H, Stein P, Hosking B . Determination of the effective dose rate for monepantel (AAD 1566) against adult gastro-intestinal nematodes in sheep. Int J Parasitol. 2008; 39(4):443-6. DOI: 10.1016/j.ijpara.2008.09.009. View