Multiple Two-component Systems of Streptococcus Mutans Regulate Agmatine Deiminase Gene Expression and Stress Tolerance

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2009 Sep 29

PMID 19783635

Citations 19

Authors

Yaling Liu

Robert A Burne

Affiliations

Soon will be listed here.

Abstract

Induction of the agmatine deiminase system (AgDS) of Streptococcus mutans requires agmatine and is optimal at low pH. We show here that the VicRK, ComDE, and CiaRH two-component systems influence AgDS gene expression in response to acidic and thermal stresses.

Citing Articles

Potential oral probiotic Lactobacillus pentosus MJM60383 inhibits Streptococcus mutans biofilm formation by inhibiting sucrose decomposition.

Gu M, Cho J, Suh J, Cheng J J Oral Microbiol. 2023; 15(1):2161179.

PMID: 36605406 PMC: 9809368. DOI: 10.1080/20002297.2022.2161179.

Mechanistic insights into the inhibitory effect of theaflavins on virulence factors production in Streptococcus mutans.

Kong J, Xia K, Su X, Zheng X, Diao C, Yang X AMB Express. 2021; 11(1):102.

PMID: 34244882 PMC: 8271058. DOI: 10.1186/s13568-021-01263-z.

An Inventory of CiaR-Dependent Small Regulatory RNAs in .

Jabbour N, Lartigue M Front Microbiol. 2021; 12:669396.

PMID: 34113330 PMC: 8186281. DOI: 10.3389/fmicb.2021.669396.

Theaflavin-3,3'-Digallate Suppresses Biofilm Formation, Acid Production, and Acid Tolerance in by Targeting Virulence Factors.

Wang S, Wang Y, Wang Y, Duan Z, Ling Z, Wu W Front Microbiol. 2019; 10:1705.

PMID: 31404326 PMC: 6676744. DOI: 10.3389/fmicb.2019.01705.

The Biology of .

Lemos J, Palmer S, Zeng L, Wen Z, Kajfasz J, Freires I Microbiol Spectr. 2019; 7(1).

PMID: 30657107 PMC: 6615571. DOI: 10.1128/microbiolspec.GPP3-0051-2018.

References

Belli W, Marquis R . Adaptation of Streptococcus mutans and Enterococcus hirae to acid stress in continuous culture. Appl Environ Microbiol. 1991; 57(4):1134-8. PMC: 182857. DOI: 10.1128/aem.57.4.1134-1138.1991. View

Li Y, Hanna M, Svensater G, Ellen R, Cvitkovitch D . Cell density modulates acid adaptation in Streptococcus mutans: implications for survival in biofilms. J Bacteriol. 2001; 183(23):6875-84. PMC: 95529. DOI: 10.1128/JB.183.23.6875-6884.2001. View

Burne R, Chen Y, Wexler D, Kuramitsu H, Bowen W . Cariogenicity of Streptococcus mutans strains with defects in fructan metabolism assessed in a program-fed specific-pathogen-free rat model. J Dent Res. 1996; 75(8):1572-7. DOI: 10.1177/00220345960750080801. View

Qi F, Merritt J, Lux R, Shi W . Inactivation of the ciaH Gene in Streptococcus mutans diminishes mutacin production and competence development, alters sucrose-dependent biofilm formation, and reduces stress tolerance. Infect Immun. 2004; 72(8):4895-9. PMC: 470703. DOI: 10.1128/IAI.72.8.4895-4899.2004. View

Ahn S, Wen Z, Burne R . Multilevel control of competence development and stress tolerance in Streptococcus mutans UA159. Infect Immun. 2006; 74(3):1631-42. PMC: 1418624. DOI: 10.1128/IAI.74.3.1631-1642.2006. View

Quivey Jr R, Faustoferri R, Reyes S . UV-resistance of acid-adapted Streptococcus mutans. Dev Biol Stand. 1995; 85:393-8. View

Senadheera M, Guggenheim B, Spatafora G, Huang Y, Choi J, Hung D . A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development. J Bacteriol. 2005; 187(12):4064-76. PMC: 1151735. DOI: 10.1128/JB.187.12.4064-4076.2005. View

Li Y, Tang N, Aspiras M, Lau P, Lee J, Ellen R . A quorum-sensing signaling system essential for genetic competence in Streptococcus mutans is involved in biofilm formation. J Bacteriol. 2002; 184(10):2699-708. PMC: 135014. DOI: 10.1128/JB.184.10.2699-2708.2002. View

Quivey Jr R, Faustoferri R, Clancy K, Marquis R . Acid adaptation in Streptococcus mutans UA159 alleviates sensitization to environmental stress due to RecA deficiency. FEMS Microbiol Lett. 1995; 126(3):257-61. DOI: 10.1111/j.1574-6968.1995.tb07427.x. View

10.

Liu Y, Burne R . Multiple two-component systems modulate alkali generation in Streptococcus gordonii in response to environmental stresses. J Bacteriol. 2009; 191(23):7353-62. PMC: 2786566. DOI: 10.1128/JB.01053-09. View

11.

Ahn S, Burne R . Effects of oxygen on biofilm formation and the AtlA autolysin of Streptococcus mutans. J Bacteriol. 2007; 189(17):6293-302. PMC: 1951938. DOI: 10.1128/JB.00546-07. View

12.

Leblanc D, Hassell F . Transformation of Streptococcus sanguis Challis by plasmid deoxyribonucleic acid from Streptococcus faecalis. J Bacteriol. 1976; 128(1):347-55. PMC: 232861. DOI: 10.1128/jb.128.1.347-355.1976. View

13.

Griswold A, Jameson-Lee M, Burne R . Regulation and physiologic significance of the agmatine deiminase system of Streptococcus mutans UA159. J Bacteriol. 2006; 188(3):834-41. PMC: 1347362. DOI: 10.1128/JB.188.3.834-841.2006. View

14.

Kreth J, Hung D, Merritt J, Perry J, Zhu L, Goodman S . The response regulator ComE in Streptococcus mutans functions both as a transcription activator of mutacin production and repressor of CSP biosynthesis. Microbiology (Reading). 2007; 153(Pt 6):1799-1807. PMC: 2062498. DOI: 10.1099/mic.0.2007/005975-0. View

15.

Hamilton I, Buckley N . Adaptation by Streptococcus mutans to acid tolerance. Oral Microbiol Immunol. 1991; 6(2):65-71. DOI: 10.1111/j.1399-302x.1991.tb00453.x. View

16.

Chong P, Drake L, Biswas I . LiaS regulates virulence factor expression in Streptococcus mutans. Infect Immun. 2008; 76(7):3093-9. PMC: 2446727. DOI: 10.1128/IAI.01627-07. View

17.

Liu Y, Zeng L, Burne R . AguR is required for induction of the Streptococcus mutans agmatine deiminase system by low pH and agmatine. Appl Environ Microbiol. 2009; 75(9):2629-37. PMC: 2681689. DOI: 10.1128/AEM.02145-08. View

18.

Biswas I, Drake L, Erkina D, Biswas S . Involvement of sensor kinases in the stress tolerance response of Streptococcus mutans. J Bacteriol. 2007; 190(1):68-77. PMC: 2223747. DOI: 10.1128/JB.00990-07. View

19.

Beier D, Gross R . Regulation of bacterial virulence by two-component systems. Curr Opin Microbiol. 2006; 9(2):143-52. DOI: 10.1016/j.mib.2006.01.005. View

20.

Li Y, Lau P, Tang N, Svensater G, Ellen R, Cvitkovitch D . Novel two-component regulatory system involved in biofilm formation and acid resistance in Streptococcus mutans. J Bacteriol. 2002; 184(22):6333-42. PMC: 151940. DOI: 10.1128/JB.184.22.6333-6342.2002. View