Cloning of an AroF Allele Encoding a Tyrosine-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate Synthase

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1990 Nov 1

PMID 1977738

Citations 20

Authors

L M Weaver

K M Herrmann

Affiliations

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Abstract

In Escherichia coli, genes aroF+, aroG+, and aroH+ encode isoenzymes of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthases that are feedback inhibited by tyrosine, phenylalanine, and tryptophan, respectively. A single base pair change in aroF causes a Pro-148-to-Leu-148 substitution and results in a tyrosine-insensitive enzyme.

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