Fibroblast Growth Factor 23 and Its Role in Phosphate Homeostasis

Overview

Journal Eur J Endocrinol

Publisher Oxford University Press

Specialty Endocrinology

Date 2009 Sep 25

PMID 19776202

Citations 27

Authors

Isolde Ramon

Pierre Kleynen

Jean-Jacques Body

Rafik Karmali

Affiliations

Soon will be listed here.

Abstract

Phosphate homeostasis is complex and incompletely understood. The identification of different factors involved in the regulation of phosphate balance, also called phosphatonins, has largely changed our view on the regulation of phosphate homeostasis. The active role of bone has been demonstrated clearly. Currently, maintaining phosphate homeostasis is considered the result of a complex network of endocrine feedback loops between parathyroid gland, kidney, and bone. This review describes current knowledge on fibroblast growth factor 23, which is one of the best studied phosphatonins.

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