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Two Components of Long-term Potentiation Induced by Different Patterns of Afferent Activation

Overview
Journal Nature
Specialty Science
Date 1990 Oct 4
PMID 1977084
Citations 196
Authors
L M Grover
T J Teyler
Affiliations
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Abstract

Long-term potentiation (LTP) of excitatory synaptic transmission could be a mechanism underlying memory. Induction of LTP requires Ca2+ influx into postsynaptic neurons through ion channels gated by NMDA (N-methyl-D-aspartate) receptors in hippocampus (area CA1 and dentate gyrus) and neocortex. Here we report that a component of LTP not requiring the activation of NMDA receptors can be induced in area CA1. The component is dependent on tetanus frequency, requires increases in postsynaptic intracellular Ca2+ concentrations, and is suppressed by an antagonist of voltage-dependent Ca2+ channels.

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