In Vivo Cellular Tropism of Human T-cell Leukemia Virus Type 1

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1990 Nov 1

PMID 1976827

Citations 168

Authors

J H Richardson

A J Edwards

J K Cruickshank

P Rudge

A G Dalgleish

Affiliations

Soon will be listed here.

Abstract

To establish the phenotype of human T-cell leukemia virus type 1 (HTLV-1)-infected cells in peripheral blood, the polymerase chain reaction was used to detect and quantitate viral DNA in subpopulations of leukocytes obtained from patients with tropical spastic paraparesis and asymptomatic carriers. HTLV-1 could not be detected in peripheral blood mononuclear cells thoroughly depleted of T lymphocytes (E- CD3-), nor could it be detected in highly enriched populations of B lymphocytes (E- CD19+), monocytes (E- CD14+), or natural killer cells (E- CD16+). T lymphocytes were strongly positive for HTLV-1, and fractionation of this population revealed that 90 to 99% of the HTLV-1 DNA segregated with the CD4+ CD8- and CD45RO+ subsets. No difference between the cell type distribution of HTLV-1 in the asymptomatic carrier and the subjects with tropical spastic paraparesis was evident. Southern hybridization of genomic DNA prepared from the peripheral blood of HTLV-1 carriers indicated that up to 10% of circulating leukocytes may carry the HTLV-1 provirus.

Citing Articles

T-Cell Receptor/CD3 Downregulation and Impaired Signaling in HTLV-1-Infected CD4+ T Cells of HAM Patients.

Nozuma S, Matsuzaki T, Tanaka M, Kodama D, Dozono M, Yoshida T Int J Mol Sci. 2025; 26(4).

PMID: 40004169 PMC: 11855110. DOI: 10.3390/ijms26041706.

Integrative analysis of ATAC-seq and RNA-seq for cells infected by human T-cell leukemia virus type 1.

Tanaka A, Ishitsuka Y, Ohta H, Takenouchi N, Nakagawa M, Koh K PLoS Comput Biol. 2025; 21(1):e1012690.

PMID: 39746113 PMC: 11753684. DOI: 10.1371/journal.pcbi.1012690.

Current State of Therapeutics for HTLV-1.

Wang T, Hirons A, Doerflinger M, Morris K, Ledger S, Purcell D Viruses. 2024; 16(10).

PMID: 39459949 PMC: 11512412. DOI: 10.3390/v16101616.

The Assembly of HTLV-1-How Does It Differ from HIV-1?.

Herrmann D, Meng S, Yang H, Mansky L, Saad J Viruses. 2024; 16(10).

PMID: 39459862 PMC: 11512237. DOI: 10.3390/v16101528.

Human Viral Oncoproteins and Ubiquitin-Proteasome System.

Atani Z, Hosseini S, Goudarzi H, Faghihloo E Glob Med Genet. 2024; 11(4):285-296.

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