The Role of Circulating Mesenchymal Progenitor Cells, Fibrocytes, in Promoting Pulmonary Fibrosis

Overview

Journal Trans Am Clin Climatol Assoc

Specialty Rehabilitation Medicine

Date 2009 Sep 22

PMID 19768162

Citations 48

Authors

Robert M Strieter

Ellen C Keeley

Marie D Burdick

Borna Mehrad

Affiliations

Soon will be listed here.

Abstract

The resident fibroblast has been traditionally viewed as the primary cell involved in promoting pulmonary fibrosis. However, contemporary findings now support the concept of a circulating cell (fibrocyte) that also contributes to pulmonary fibrosis. Fibrocytes are bone marrow-derived mesenchymal progenitor cells that express a variety of cell surface markers related to leukocytes, hematopoietic progenitor cells and fibroblasts. Fibrocytes are unique in that they are capable of differentiating into fibroblasts and myofibroblasts, as well as adipocytes. In this review, we present data supporting the critical role these cells play in the pathogenesis of pulmonary fibrosis.

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