Nutritional State Influences Nociceptin/Orphanin FQ Peptide Receptor Expression in the Dorsal Raphe Nucleus

Overview

Journal Behav Brain Res

Specialties Neurology
Psychology
Social Sciences

Date 2009 Sep 22

PMID 19765615

Citations 5

Authors

Magdalena J Przydzial

Alastair S Garfield

Daniel D Lam

Stephen P Moore

Mark L Evans

Lora K Heisler

Affiliations

Soon will be listed here.

Abstract

Agonists of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor stimulate food intake. Concordantly, neuroanatomical localization of NOP receptor mRNA has revealed it to be highly expressed in brain regions associated with the regulation of energy balance. However, the specific mechanisms and neurochemical pathways through which physiological N/OFQ influences appetite are not well understood. To investigate this, we examined nutritional state-associated changes in NOP receptor mRNA levels throughout the rostrocaudal extent of the rat brain using in situ hybridization histochemistry (ISHH) and quantitative densitometry analysis. We observed a significant downregulation of NOP receptor mRNA in the dorsal raphe nucleus (DRN) of fasted rats compared to free-feeding rats. In contrast, no difference in NOP receptor mRNA expression was observed in the supraoptic, parventricular, ventromedial, arcuate or dorsomedial nuclei of the hypothalamus, the red nucleus, the locus coeruleus or the hypoglossal nucleus in the fasted or fed state. These data suggest that the endogenous N/OFQ system is responsive to changes in energy balance and that NOP receptors specifically within the DRN may be physiologically relevant to N/OFQ's effects on appetite.

Citing Articles

The Opioid System in Rainbow Trout Telencephalon Is Probably Involved in the Hedonic Regulation of Food Intake.

Diaz-Rua A, Chivite M, Comesana S, Conde-Sieira M, Soengas J Front Physiol. 2022; 13:800218.

PMID: 35299666 PMC: 8921556. DOI: 10.3389/fphys.2022.800218.

Parsing the hedonic and motivational influences of nociceptin on feeding using licking microstructure analysis in mice.

Mendez I, Maidment N, Murphy N Behav Pharmacol. 2016; 27(6):516-27.

PMID: 27100061 PMC: 4965319. DOI: 10.1097/FBP.0000000000000240.

Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating.

Hardaway J, Jensen J, Kim M, Mazzone C, Sugam J, DiBerto J Behav Brain Res. 2016; 307:25-34.

PMID: 27036650 PMC: 4896639. DOI: 10.1016/j.bbr.2016.03.046.

Gender differences in Nociceptin/Orphanin FQ-induced food intake in strains derived from rats prone (WOKW) and resistant (Dark Agouti) to metabolic syndrome: a possible involvement of the cocaine- and amphetamine-regulated transcript system.

Battistoni S, Kloting I, Cifani C, Massi M, Polidori C Genes Nutr. 2011; 6(2):197-202.

PMID: 21484154 PMC: 3092911. DOI: 10.1007/s12263-010-0189-3.

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10.

Garfield A, Cowley M, Smith F, Moorwood K, Stewart-Cox J, Gilroy K Nature. 2011; 469(7331):534-8.

PMID: 21270893 PMC: 3031026. DOI: 10.1038/nature09651.

References

Polidori C, Calo G, Ciccocioppo R, Guerrini R, Regoli D, Massi M . Pharmacological characterization of the nociceptin receptor mediating hyperphagia: identification of a selective antagonist. Psychopharmacology (Berl). 2000; 148(4):430-7. DOI: 10.1007/s002130050073. View

Fukuda K, Kato S, Mori K, Nishi M, Takeshima H, Iwabe N . cDNA cloning and regional distribution of a novel member of the opioid receptor family. FEBS Lett. 1994; 343(1):42-6. DOI: 10.1016/0014-5793(94)80603-9. View

Simansky K . Serotonergic control of the organization of feeding and satiety. Behav Brain Res. 1996; 73(1-2):37-42. DOI: 10.1016/0166-4328(96)00066-6. View

Liu H, Kishi T, Roseberry A, Cai X, Lee C, Montez J . Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci. 2003; 23(18):7143-54. PMC: 6740648. View

Bomberg E, Grace M, Levine A, Olszewski P . Functional interaction between nociceptin/orphanin FQ and alpha-melanocyte-stimulating hormone in the regulation of feeding. Peptides. 2006; 27(7):1827-34. DOI: 10.1016/j.peptides.2006.02.007. View

Paxinos G, Watson C, Emson P . AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. J Neurosci Methods. 1980; 3(2):129-49. DOI: 10.1016/0165-0270(80)90021-7. View

Olszewski P, Grace M, Billington C, Levine A . The effect of [Phe(1)psi(CH(2)-NH)Gly(2)]-nociceptin(1-13)NH(2) on feeding and c-Fos immunoreactivity in selected brain sites. Brain Res. 2000; 876(1-2):95-102. DOI: 10.1016/s0006-8993(00)02603-2. View

Schwartz M, Woods S, Porte Jr D, Seeley R, Baskin D . Central nervous system control of food intake. Nature. 2000; 404(6778):661-71. DOI: 10.1038/35007534. View

Abbasnejad M, Jonaidi H, Denbow D, Pour Rahimi A . Feeding and locomotion responses to centrally injected nociceptin/orphanin FQ in chicks. Physiol Behav. 2005; 85(4):383-6. DOI: 10.1016/j.physbeh.2005.03.016. View

10.

Filippetti R, Kloting I, Massi M, Cifani C, Polidori C . Involvement of cocaine-amphetamine regulated transcript in the differential feeding responses to nociceptin/orphanin FQ in dark agouti and Wistar Ottawa Karlsburg W rats. Peptides. 2007; 28(10):1966-73. DOI: 10.1016/j.peptides.2007.08.003. View

11.

Reinscheid R, Nothacker H, Bourson A, Ardati A, Henningsen R, Bunzow J . Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor. Science. 1995; 270(5237):792-4. DOI: 10.1126/science.270.5237.792. View

12.

Stratford T, Holahan M, Kelley A . Injections of nociceptin into nucleus accumbens shell or ventromedial hypothalamic nucleus increase food intake. Neuroreport. 1997; 8(2):423-6. DOI: 10.1097/00001756-199701200-00009. View

13.

Olszewski P, Billington C, Levine A . Fos expression in feeding-related brain areas following intracerebroventricular administration of orphanin FQ in rats. Brain Res. 2000; 855(1):171-5. DOI: 10.1016/s0006-8993(99)02239-8. View

14.

Le Maitre E, Vilpoux C, Costentin J, Leroux-Nicollet I . Opioid receptor-like 1 (NOP) receptors in the rat dorsal raphe nucleus: evidence for localization on serotoninergic neurons and functional adaptation after 5,7-dihydroxytryptamine lesion. J Neurosci Res. 2005; 81(4):488-96. DOI: 10.1002/jnr.20571. View

15.

Sawchenko P, Swanson L, Joseph S . The distribution and cells of origin of ACTH(1-39)-stained varicosities in the paraventricular and supraoptic nuclei. Brain Res. 1982; 232(2):365-74. DOI: 10.1016/0006-8993(82)90280-3. View

16.

Neal Jr C, Mansour A, Reinscheid R, Nothacker H, Civelli O, Akil H . Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: comparison of ORL1 receptor mRNA expression with (125)I-[(14)Tyr]-orphanin FQ binding. J Comp Neurol. 1999; 412(4):563-605. View

17.

Elmquist J, Elias C, Saper C . From lesions to leptin: hypothalamic control of food intake and body weight. Neuron. 1999; 22(2):221-32. DOI: 10.1016/s0896-6273(00)81084-3. View

18.

Meunier J, Mollereau C, Toll L, Suaudeau C, Moisand C, Alvinerie P . Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature. 1995; 377(6549):532-5. DOI: 10.1038/377532a0. View

19.

Polidori C, De Caro G, Massi M . The hyperphagic effect of nociceptin/orphanin FQ in rats. Peptides. 2000; 21(7):1051-62. DOI: 10.1016/s0196-9781(00)00243-6. View

20.

Rodi D, Polidori C, Bregola G, Zucchini S, Simonato M, Massi M . Pro-nociceptin/orphanin FQ and NOP receptor mRNA levels in the forebrain of food deprived rats. Brain Res. 2002; 957(2):354-61. DOI: 10.1016/s0006-8993(02)03678-8. View